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Showing 1 to 9 of 9 for “"Soluplus®"”.
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Investigation of injection moulding for novel drug delivery systems. An investigation into the use of injection moulding to produce pharmaceutical dosage forms and to understand the relationship between materials, processing conditions and performance, in particular drug release and stability
… succinate (HPMCAS) and a graft co-polymer (Soluplus®). BCS class II drugs ibuprofen and the felodipine were selected based on their physicochemical properties. In the present work, a homogenous dispersion of drugs in the polymer matrices was achieved using Hot Melt Extrusion (HME) and …
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Influence of novel techniques on solubility, mechanical properties and permeability via hot melt extrusion technology
… formulated in Eudragit® EPO/ Kollidon® VA 64 or Soluplus® formulation was used in this study to investigate the efficiency of various polymers to enhance the solubility and permeability of piperine via HME technique to ultimately increase its systemic absorption of the compound. Scanning electron …
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Fused deposition modelling three-dimensional printing of solid dosage forms
… (PVA), Hydroxypropyl Cellulose (HPC), and Soluplus®). FDM-3DP enabled the manufacture of monolithic and non-monolithic floating drug delivery systems using a sandwich design. The tablet design showed the ability to achieve prolonged gastric floating (12 hours) with no floating lag time. …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
<p>Soluplus® (SOL), a graft amorphous copolymer, composed of polyethylene glycol, vinyl acetate and vinylcaprolactam in a ratio of 13: 30: 57, was utilized to prepare solid dispersions containing felodipine (FEL) or ketoconazole (KTZ) using hot-melt extrusion technology. The melting point …
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Investigating Controlled Release Pulmonary Drug Delivery Systems
… possible. A commercially available polymer, Soluplus® was spray-dried with a poorly-water soluble corticosteroid, beclomethasone dipropionate (BDP). The resultant respirable powders were shown to have potential for use as a controlled release pulmonary drug delivery system with up to 7-fold …
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Characterization of different hydrophilic polymers and their applicability in hot melt extrusion technology
… the feasibility of producing stable drug-loaded Soluplus® extrudates utilizing HME technology, and to study the influence of formulation and processing parameters such as drug-load and heating duration, respectively, on the drug-polymer miscibility as well as the release from melt extrudates; (4) …
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Novel formulations of a poorly soluble drug using the extrusion process.
… processing HME. A low Tg amphiphillic copolymer, Soluplus® was selected as a matrix material. Drug-polymer compatibility was studied using rotational rheometry and thermal characterisation. The drug was found to be completely dissolved within the polymer, although some discolouration of the …
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Solubility enhancement, mechanical properties and taste masking of poorly water soluble compounds by optimizing hot melt extrusion processing
… maximized sphericity and hardness utilizing Soluplus® as a polymeric carrier and carbamazepine (CBZ) as a model drug; (4) To assess the potential of Lutrol® F grades as polymeric surfactants for solubility enhancement of Kollidon®VA64 drug matrices produced by Hot Melt Extrusion.
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Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms
… while polyvinyl caprolactam graft copolymer, Soluplus® (SOL) and vinylpyrrolidone-vinyl acetate copolymer grades Kollidon® VA64 (VA64) and Plasdone® S630 (S630) were used as hydrophilic polymeric carriers. For the purpose of the study, all drug-polymer binary blends at various ratios were …