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Showing 1 to 8 of 8 for “"Soluble guanylyl cyclase"”.

  1. Structure and dynamics of soluble guanylyl cyclase

    Sugino, Kentaro

    Soluble guanylyl cyclase (sGC) is one of the key enzymes involved in many fundamental biological processes including vasodilatation. It can be allosterically activated by synthetic compound such as YC-l. Recently, the 3D structure of adenylyl cyclase (AC), which is a homologue of sGC, was …

    njit Repository record

  2. Regulation of the nitric oxide receptor, soluble guanylyl cyclase

    Nedvetsky, Pavel I.Universität Würzburg

    Soluble guanylyl cyclase (sGC) is the best established receptor for nitric oxide (NO) and regulates a great number of important physiological functions. Surprisingly, despite the wellappreciated roles of this enzyme in regulation of vascular tone, smooth muscle cell proliferation, platelet …

    wurz-thes Repository record

  3. No-Independent Modulation of Soluble Guanylyl Cyclase (Sgc) Activity and Function

    Britton, George L, Jr2014

    <p>Soluble guanylyl cyclase (sGC) plays a key role in the nitric oxide (NO) signaling pathway, where it functions as an NO receptor and generator of a secondary intracellular messenger, cGMP. In addition to NO, investigators have identified a number of proteins that interact with sGC and modulate …

    uthsc Repository record

  4. Functional importance of the soluble guanylyl cyclase isoforms (sGCα1β1 and sGCα2β1) in vascular smooth muscle relaxation

    Nimmegeers, Sofie2008

    ghent Repository record

  5. OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION

    Bolin, Celeste Maree

    … acid, and evidence of oxo8GTP as an inhibitor of soluble guanylyl cyclase (sGC). A significant induction of oxo8GTP in cell-free preparations as well as in PC12 and HEK 293T cells exposed to physiologically relevant oxidative conditions generated with 10 ?M copper sulphate and 1mM L-Ascorbic Acid …

    montana-tech Repository record

  6. OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION

    Bolin, Celeste Maree

    … acid, and evidence of oxo8GTP as an inhibitor of soluble guanylyl cyclase (sGC). A significant induction of oxo8GTP in cell-free preparations as well as in PC12 and HEK 293T cells exposed to physiologically relevant oxidative conditions generated with 10 ?M copper sulphate and 1mM L-Ascorbic Acid …

    montana Repository record

  7. Repulsive cues and signalling cascades of the axon growth cone

    Manns, Richard Peter CharlesUniversity of Cambridge2013

    … concentration-independent and does not involve guanylyl cyclase, but it does share a dependence upon mTOR activity and the synthesis of RhoA, sufficient to cause collapse downstream of Semaphorin-3A. The other axon-repelling domain of Nogo-A, Nogo-66, is partially dependent upon the proteasome …

    cambridge Repository record

  8. MOLECULAR AND FUNCTIONAL CHARACTERISATION OF THE ROLE OF HYDROGEN SULPHIDE IN SEXUAL MEDICINE

    ROESWITA LEONO LIAW2011

    … of both the active and inactive forms of soluble guanylyl cyclase (sGC) ß1 and stimulating the translocation of sGCa1 from the cytosol to the membrane. Overall, H2S seems to play a `supportive¿ role with respect to NO pathway in erectile physiology, amplifying NO signalling through dual …

    nus Repository record