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Showing 1 to 20 of 24 for “"Solubility enhancement"”.
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Solubility enhancement of poorly water soluble drugs using liposome technology
… single chain surfactant a-tocopherol resulted in enhancement of drug loading and possibly is governed by the log P of the drug candidate. Environmental scanning-electron microscopy (ESEM) was used to dynamically follow the changes in liposome morphology in real time during dehydration thereby …
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Solubility Enhancement via Melt Extrusion: Drug-polymer Solubility, Physicochemical Characterization and Quality by Design
… is a very widely applied technique for solubility enhancement of water insoluble drugs. In order to form stable solid dispersions it is important to select appropriate excipients that will maintain the drug in its amorphous form for an extended period of time. Selection of appropriate …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… was utilized to determine the miscibility and solubility of the model compounds within Soluplus® , of which felodipine demonstrated higher solubility when compared to ketoconazole (14% vs 4.3% w/w) at room temperature (298K). Moreover, the solubility parameters of FEL, KTZ and SOL were …
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Solubility enhancement, mechanical properties and taste masking of poorly water soluble compounds by optimizing hot melt extrusion processing
… research focusing on actives with low aqueous solubility requires new technology to obtain tailored drug release. This research project studies the use of hot melt extrusion (HME), together with hydrophilic polymers, to improve availability of poorly soluble compounds. In recent years HME has …
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Predicting aqueous solubility of pharmaceutical agents by solid dispersion prepared by solvent evaporation method
<p>Solubility of active pharmaceutical agents is a crucial process that determines drug absorption and ultimately its bioavailability. Many of the new therapeutically beneficial compounds discovered are lipophilic requiring various solubility enhancement strategies to improve their solubility. …
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Determination of the water solubility of the fungicide chlorothalonil
… was developed and used to measure the water solubility of chlorothalonil at temperatures ranging from 8.5 to 37.5 °C. The effect of formulation chemicals present in BRAVO®500, a pesticide formulation containing chlorothalonil, on the apparent water solubility of chlorothalonil was also …
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Characterization of different hydrophilic polymers and their applicability in hot melt extrusion technology
… studied under current research have low aqueous solubility, it was necessary to utilize a novel technology such as hot melt extrusion (HME) in combination with hydrophilic polymers to obtain tailored drug release. Over recent years HME technology has found widespread application as a viable drug …
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Computational prediction of enhanced solubility of poorly aqueous soluble drugs prepared by hot melt method
<p>Solubility is the concentration of a solute in a saturated solution at a given temperature and pressure. Solubility of a drug in aqueous media is a pre-requisite to achieve desired concentration of a drug in the systemic circulation. Low aqueous solubility is a major problem encountered with …
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Studies of hydrophobic organic pollutant interactions with cyclodextrin: implication for groundwater remediation
… increasing CD concentration due to an apparent solubility enhancement caused by HOP partitioning to the hydrophobic cavity of CD molecules. The temperature dependence of air-water partitioning under the influence of CD was well described by the van’t Hoff equation for all HOPs tested. A …
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
… drying is widely used in enhancing the aqueous solubility of poorly soluble compounds. In this study, the mechanism of solubility enhancement was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and spray …
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Versatility of hot-melt extrusion for dosage form design
… ways to achieve different goals, such as solubility enhancement, taste masking, solid state stability enhancement, and sustained release formulations for oral drug delivery, using one model drug, mefenamic acid. For solubility enhancement and taste masking formulations, Eudragit EPO was …
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The Modification of Solvents for Liquid-Liquid Extraction Processes
… but these compounds are added to influence the solubility curve. In a preliminary study of these effects, it was noticed that polar molecules affected the tie-lines more than the solubility. Therefore, in depth study of the ternary systems, namely: Acetone - Toluene - Water, Methanol - Xylene- …
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Chemical Modification of Alginates in Organic Media
… of concept study showed their utility in the solubility enhancement of the poorly water soluble flavonoid naringenin.
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The Formation of Pharmaceutical Co-crystals by Spray Drying. An Investigation into the Chemical and Physical Factors Affecting the Production of Pharmaceutical Co-crystals by Fast Evaporation and Spray Drying
… and THEO with di-carboxylic acids acquires large solubility difference which is important to consider for its utility in product development. Based on previous assumption that maleic acid (MAL) elevates CAF’s solubility; solubility of the two similar compounds was tested in various dicarboxylic …
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Dissolution Behavior of Amorphous Solid Dispersions
… number of new drug compounds have extremely poor solubility in water, impacting the bioavailability of the drug. Solubility enhancement techniques, such as amorphous solid dispersions (ASDs), can be used in oral dosage forms to increase the apparent solubility of the drug in the gastrointestinal …
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A study of the mechanisms of milling-induced enhancement of solubility and dissolution rate of poorly soluble drugs
… techniques that have potential to enhance the solubility and/or dissolution rate of poorly soluble drugs. There are broadly two aims for this project. The first was to develop an understanding of how individual and combination of techniques may be used to explore the impact of milling on …
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A Dual Approach of Salt Formation and Amorphous Solid Dispersion for Improved Oral Drug Delivery
… and suboptimal therapeutic outcomes. Drug solubility is a crucial factor that influences the absorption and bioavailability of orally administered drugs. For a drug to be absorbed, it must first dissolve in the GI fluid and then permeate through the intestinal membrane. Poorly water-soluble …
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Synthesis and characterisation of new multi-component compounds containing the non-steroidal anti-inflammatory drugs fenbufen and S(+)-ibuprofen
… anti-inflammatory drugs with poor aqueous solubility. In attempts to improve their solubility and bioavailability, crystal engineering techniques were employed to synthesise salts, co-crystals and cyclodextrin inclusion complexes containing these drugs. All newly discovered phases were …
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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
<p>Solubility behavior is one of the most challenging aspects for drug commercialization and often the main reason of drug that do not reach to its full potential. Now nearly 60% new chemical entities possess solubility problems, whereas practically no drug products with less than 10 µg/ml …
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Solubility Improvement by Solid Dispersion and Their Characterization: Indomethacin and Phenytoin
The objective of this project was to improve the solubility of two poorly water soluble drugs, namely indomethacin and phenytoin by formulating ternary solid dispersions with a carrier and an adsorbent. Urea was used as the dispersing agent for indomethacin, while Kollidon<sup>®</sup>VA64 was used …
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