Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Solid-state nanopore"”.
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Solid-state nanopore sensors for nucleic acid analysis
Nanopore DNA analysis is an emerging technique that involves electrophoretically driving DNA molecules through a nano-scale pore in solution and monitoring the corresponding change in ionic pore current. This versatile approach permits the label-free, amplification-free analysis of charged polymers …
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Atomically thin solid-state nanopore field-effect transistors for single-molecule sensing
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Membrane transfer process for the creation of low-noise solid state nanopore devices
Nanopore sensors are an emerging technology whereby the modulation of a current trace upon passage of the analyte through the nanopore is used to infer the properties of the analyte. This technology is particularly attractive because it is label-free, rapid, and intrinsically single molecule. …
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Molecular Sensing with Protein and Solid-State Nanopores
<p>In the past 15 years nanopore sensing has proven to be a successful method for probing a variety of molecules of biological interest, such as DNA, RNA and proteins. Of particular appeal is this technique's ability to probe these molecules without the need for chemical modification or labeling, …
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Improving the Signal-to-Noise of Nanopore Sensors
Over the last five years, solid state nanopore technology advanced to rival biological pores as a platform for next generation DNA sequencing. Fabrication improvements led to a reduction in nanopore diameter and membrane thickness, offering high precision sensing. Custom electronics were developed …
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Noise Optimization for High-Bandwidth Ion Channel Recordings
… to closely incorporate this amplifier with solid-state nanopore sensors, lipid membranes, and biological ion channels. The low capacitance of these integrated platforms reduces noise at high frequencies, enabling signals to be measured up to ten times faster than had been previously …
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Graphene supported hafnium oxide nanopores for DNA sensing
… behind personalized medicine. In this work, state-of-the-art sequencing technologies are reviewed and compared with next-generation sequencing technologies. In particular, solid-state nanopores are investigated and recent developments in the field are discussed. The interdisciplinary effort …
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Detection of Nucleic Acid Disease Biomarkers Using Solid-State Nanopores
Nanopore sensing technology was initiated with the ultimate goal of developing a rapid, single-molecule sequencer. With the release of Oxford Nanopore Technology’s Minion sensor in 2014, that goal has been achieved. While this device utilizes biological nanopores, Solid-State Nanopore sensors were …
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Ion transport in multilayer solid-state nanopores for memory and biosensing applications
Solid-state nanopores have emerged as powerful platforms for investigating nanoscale transport phenomena and single-molecule sensing, owing to their structural robustness, chemical stability, and ability to simultaneously probe ionic and in-plane currents during biomolecule translocation. This …
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DNA translocation through an array of kinked nanopores
Synthetic solid-state nanopores are being intensively investigated as single-molecule sensors for detection and characterization of DNA, RNA, and proteins. This field has been inspired by the exquisite selectivity and flux demonstrated by natural biological channels and the dream of emulating these …
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Integrated Analog Readout Array and Digital Backend for Mobile DNA Sequencing
… sequencing. An innovative approach to this is nanopore-based DNA sequencing. Unlike many other methods, nanopore sequencing detects DNA molecules directly, rather than relying on secondary phenomena, and can do so in real-time as the molecules pass through the device. This technology holds the …
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Decoding the Fabric of Life: Nanopore Sensing of Nucleic Acid Structure from the Primary to the Quaternary
… thesis, I leveraged RNA/DNA nanotechnology and solid-state nanopore sensing to detect RNA structural modifications and to characterise the kinetics of nanostructure formation. Additionally, I aimed to directly identify triplexes solely using nanopore sensing. The group’s RNA Single-nucleotide …
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Single-Molecule Characterization of RNA via Nanopore Sensing
… of interest, followed by characterization via solid-state nanopore sensing. I first describe the nanopore observables and nucleic acid parameters relevant to nanostructure characterization. Then, I demonstrate how tandem implementation of nanostructure engineering and nanopore sensing can be …
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Towards a Single Bio-molecule Detector Based on CMOS Nanofluidic Platform
… and expanded in manufacturing.However, state-of-theart techniques for monitoring typically low concentrations of cytokines require either Mass Spectroscopy (MS) or immunoassays like Enzyme-linked Immunosorbent Assay (ELISA). We propose the use of CMOS technology to build a proteomic …
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Biomolecular transport at and through two-dimensional materials
… electrical conductivity enables potential nanopore sensing applications for controllable nanofluidics and nanopore sensing applications conducive towards biomolecule sequencing. A nanopore sequencer operates by recording the ionic current as a single-stranded DNA molecule is …