Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 199 for “"Solid-state NMR"”.
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Solid-State NMR: investigations of biomolecular structure
Solid-state nuclear magnetic resonance methods were used to characterize the structure of biological molecules in lyophilized and hydrated environments with and without the presence of other molecules such as drugs, lipids, and surfaces. Revealing the structure of biomolecules by mimicking its …
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Development of new methods in solid-state NMR
… the information that may be extracted using NMR. MAS is able to remove first-order quadrupolar broadening but can only reduce the second-order contribution to the linewidth. The MQMAS and STMAS techniques have enabled high-resolution NMR spectra of half-integer quadrupolar nuclei in the solid …
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Solid State NMR Relaxation Studies of Triosephosphate Isomerase
… essential to understanding biological function. NMR is a powerful technique for the observation of protein dynamics in that dynamics can be observed site-specifically over a wide range of timescales from picoseconds to seconds. Spin relaxation measurements, including relaxation in the rotating …
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Multidimensional Solid-State NMR Studies of Membrane Proteins
Recent progress in solid-state NMR techniques presents unique opportunities to study the structure and dynamics of membrane proteins by using uniformly or extensively isotopically labeled samples. In this work, we first optimized the performance of shaped pulses in magic-angle spinning solid-state …
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Solid-State NMR of Metallic and Paramagnetic Systems
Solid-state nuclear magnetic resonance (ssNMR) is a powerful element-specific technique to study local atomic environments in many different classes of materials; however, ssNMRbased methodologies have primarily focussed on diamagnetic systems without any unpaired electrons. In paramagnetic or …
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Solid-state NMR investigations of the bacteriorhodopsin photocycle
… This thesis describes the application of solid-state Nuclear Magnetic Resonance (NMR) to investigate each of the competing models in the native purple membrane environment. Conformational changes of the chromophore have been characterized by correlation of 13C-1H and 5N-1H dipolar …
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Solid-State NMR Studies of Polymeric and Biomembranes
… is to demonstrate different applications of ssNMR, with particular emphasis on uses in polymeric and biosciences. First, dynamics investigations on two polymers will be discussed: (1) disulfonated poly(arylene ether sulfone)s /poly(ethylene glycol) blends (BPS-20_PEG), which are under …
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Solution and solid-state NMR studies of amphotericin B
… or both of these functional groups and solution NMR conformational analysis was employed to determine the ground state conformation of AmB and our derivatives. The functional consequences of these deletions were then assessed in antifungal assays. Our results indicate that in stark contrast to …
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Solid-state NMR studies of α-synuclein fibril structure
… 3D structure of α-syn fibrils determined through solid- state NMR spectroscopy experiments validated with X-ray fiber diffraction and electron microscopy mass per-length measurements. The fibril form presented here is shown to be pathologically active in neuronal cell culture. Further, the …
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Deuterium Solid State NMR Studies of Pyridine Intercalation Compounds
A quadrupole echo deuterium NMR lineshape study on polycrystalline samples of perdeuterated pyridine and selectively deuterated d$\sb2$-pyridine intercalated into 2H-TaS$\sb2$ was performed between 280K and 393K. The powder pattern lineshapes above 333K show signs of motional narrowing. A short …
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Glycation of Extracellular Matrix: A Solid-State NMR Study
… matrix (ECM) and ribose-5-phosphate using solid-state nuclear magnetic resonance (SSNMR) spectroscopy. The background and motivations of this project are outlined in chapter 1. Chapter 2 reviews the current understanding of the composition and organisation of the ECM, the structure of …
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Exploring large coherent spin systems with solid state NMR
Solid state Nuclear Magnetic Resonance (NMR) allows us to explore a large coherent spin system and provides an ideal test-bed for studying strongly interacting multiple-spin system in a large Hilbert space. In this thesis, we experimentally investigate the spin dynamics in a rigid lattice of …
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Structural studies of amyloid fibrils using solid-state NMR
he development of solid-state NMR techniques and application to amyloid fibrils are presented. In addition, a new method of selective inversion based on chemical shift anisotropy is presented. An improved method for highly accurate distance measurement across parallel [beta]-sheets in amyloid …
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Solid-state NMR of low-gamma nuclei and solid-state NMR probe design towards minimization of the perturbation of the applied magnetic field
… that can be obtained through non-destructive solid- state NMR spectroscopy (SSNMR). The SSNMR approach can be used to obtain details about molecular- level structure andmetal-ligand interactions, leading to deeper understanding of structure-function-property relationships. In addition to …
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Characterization of semiconductor nanocrystals using advanced solid-state NMR spectroscopy
… using advanced nuclear magnetic resonance (NMR) spectroscopy methods. In general, NMR is a powerful technique for structure determination because NMR probes the local chemical environment by measuring chemical shifts or electric field gradients (EFG) and enables the connectivity/proximity of …
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Structural studies of membrane-associated complexes by solid-state NMR
… functions of the cell. This thesis utilizes solid-state nuclear magnetic resonance spectroscopy to investigate the structure of calcium-phosphatidylserine (PS) complexes that regulate blood coagulation, and to understand how interactions of the antifungal drug amphotericin B with ergosterol …
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Multinuclear Solid-State NMR Studies of Supported Transition Metal Carbonyls
… and oxygen-17 nuclear magnetic resonance (NMR) spectra have been obtained for a variety of transition metal carbonyl clusters, metal oxides, and oxide-supported metal carbonyl complexes. Magic-angle spinning (MAS) C-13 NMR spectra of polycrystalline metal carbonyl clusters yield both …
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Solid state NMR studies of oxide superconductors and related materials
Solid state nuclear magnetic resonance spectroscopy is used to obtain information on the nearest neighbor atom scale regarding various structural, electronic and magnetic properties of a variety of simple oxides, mixed metal oxides and oxide superconductors. Chapter 1 briefly reviews the basic …
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Structure and dynamics of membrane proteins from solid-state NMR
Solid-state nuclear magnetic resonance (SSNMR) spectroscopy is an essential tool to elucidate the structure, dynamics, and function of biomolecules. This thesis mainly focuses on the structure determination of the hydrophobic domains for fusion proteins which are involved in membrane fusion between …
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