Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"Solid tumours"”.
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… the tumour-infiltrating immune cells in tumours after CFA treatment were identified. In the P815 model, tumour-infiltrating neutrophils were identified as the primary infiltrating cell type, and high frequencies within the tumours early after treatment was associated with improved …
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… the tumour-infiltrating immune cells in tumours after CFA treatment were identified. In the P815 model, tumour-infiltrating neutrophils were identified as the primary infiltrating cell type, and high frequencies within the tumours early after treatment was associated with improved …
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The in vivo proliferation kinetics of human solid tumours
The study of tissue and tumour cell kinetics is one approach to better understanding of human tumour biology and to the formulation of better treatment strategies. Past efforts to measure in vivo the duration of cell cycle phases has been severely handicapped by the need to use radioisotopes and to …
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Investigating the spatiotemporal dynamics of mononuclear phagocytes in solid tumours.
… macrophages (TAM) are a universal feature of solid tumours, regardless of the cancer’s immunogenicity, but variably influence outcomes and treatment responses. DCs capture tumour antigens and upregulate CCR7, which directs their migration to secondary lymphoid organs, where they prime …
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Mathematical modelling of the innate and adaptive immune response to solid tumours
… mathematical models describing the growth of a solid tumour in the presence of an immune response are presented. Specifically, attention is focused on the interactions between cytotoxic T-lymphocytes (CTLs) and tumour cells in a small, avascular multicellular tumour. At this stage of the disease …
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
Bloodborne molecular biomarkers are increasingly emerging as significant non-invasive adjuncts to current methods of disease status evaluation in cancer patients. Investigations into the potential utility of these circulating biomarkers as analytic test measures complementing radiological imaging …
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The development of electrolysis for local destruction of solid tumours / by Guy John Maddern.
… electrolysis as a local ablative technique for solid tumours including the liver and pancreas. The work presented first establishes the feasibility of electrolytically produced lesions in small and large animal models, and then its effect on tumour cells in a small animal model.
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The oral health needs of children, adolescents and young adults after cancer therapy for solid tumours
The survival rate of children with solid tumours is increasing. As a consequence the late effects of cancer therapy have become an important issue requiring further research. The oral health of an individual is central to their general health, level of nutrition and quality of life. This study …
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Computed Tomographic Studies of Characteristics of Selected Canine Lymph Nodes Relevant to Staging and Treatment of Solid Tumours
… treatment of pelvic limb and caudal abdominal tumours in dogs. Specific objectives of this body of research were to describe the lymphatic drainage of the canine pelvic limb, characteristics of normal popliteal lymph nodes, and the location and CT characteristics of presumed normal medial iliac …
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Investigation into the role of HMGb1 in relation to myofibroblasts and cancer cells exposed to various conditions
… features of the central core of most solid tumours. Myofibroblasts are stromal cells present in many such solid tumours including those of the colon, and they are known to be involved in all stages of tumour progression. HMGb1 is a nuclear protein that plays an important role in …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
… have not responded well, particularly those with solid tumours. Understanding the biology of CART cell effector function may explain treatment failure, and lead to more effective cell therapy products. Population-based assays such as flow cytometry give a snapshot of these complex cellular …
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A study comparing the effects of vincristine with those of ionizing radiation on the root meristem of Vicia faba
… disease, lymphosarcoma and certain childhood solid tumours have also been reported.
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Late effects of treatment in survivors of childhood acute lymphoblastic leukaemia
… survivors. Control groups of children with solid tumours in long term remission showed less stunting during treatment and had catch-up growth after treatment, except when they had undergone spinal i rradi ati on. Normal endocrine function is a prerequisite for normal growth and development. …
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Ex vivo culture of patient tissue and examination of gene delivery
… mimic the transient hypoxic conditions found in solid tumours. We found that Adenoviral transgene expression was robust in the cycling hypoxic conditions relevant to solid tumours and re-oxygenation of chronically hypoxic tissue enhanced transgene expression. Finally, we demonstrated an AAV-based …
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Flourescent Biosensor-Based, Cdc42 Activity Imaging For Understanding the Regulation of Epidermal Growth Receptor (EGFR) Signalling in Head and Neck Cancer
… Receptor (EGFR) is overexpressed in several solid tumours including squamous cell carcinoma of the head & neck (SCCHN). Drugs that directly block the action of EGFR are currently available. However, a major unanswered question is; how best to select patients most likely to respond to these …
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Generation of a novel pan-cancer chemokine receptor-modified CAR-T cell therapy directed towards nfP2X7
… multiple haematological malignancies. However, solid cancers present challenges such as tumour antigen heterogeneity and complex mechanisms of immune evasion that have limited the translation of CAR-T cell therapies from haematological malignancies to solid cancers. This study details the …
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Crosstalk between natural killer cells and cancer associated fibroblasts in the tumour microenvironment
… microenvironment. Indeed, difficult to treat solid cancers, like pancreatic cancer, are rich in cancer associated fibroblasts (CAF) which support tumour growth and suppress immune cell functions. Overcoming barriers like CAF-derived immune suppression in the solid tumour microenvironment …
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Development of imaging techniques to assess tumour cell death
… in tumour size (Response Evaluation Criteria in Solid Tumours (RECIST)). More recently these assessments have also included functional and molecular information, as these parameters can show earlier responses to chemotherapies, e.g. using PET measurements of 2-[¹⁸F]-fluoro-2-deoxy D-glucose …
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Arsenic trioxide in ovarian cancer
… shown anti-tumour activity against a variety of solid tumours in vitro. However, the mechanisms responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance in ovarian cancer cells …
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A molecular genetic investigation of rhabdomyosarcoma
… malignancy, but also in translocations found in solid tumours. Mutation analysis of tumour samples and cell lines from patients with embryonal and alveolar rhabdomyosarcoma suggests that there are no subtle disease associated mutations within the P AX3 gene that could contribute towards the …
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