Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Solid phase synthesis"”.
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Solid Phase Synthesis of M-Phenylene Ethynylene Oligomer Heterosequences
The synthesis of m-phenylene ethynylene (mPE) oligomers is currently a tedious process. To address this, two methods for the solid-phase synthesis of mPE oligomers (including heterosequences) have been developed. The first strategy employs a silyl-acetylene linker attached to ArgoGel(TM) solid …
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Solution and solid phase synthesis of N,N'-diacetyl chitotetraoses
… In this report, we describe the chemical synthesis of three chitotetraoses namely GlcNAc-GlcN-GlcNAc-GlcN, GlcN-GlcNAc-GlcNAc-GlcN and GlcN-GlcN-GlcNAc-GlcNAc. Benzyloxycarbonyl (Z) and p-nitrobenzyloxycarbonyl (PNZ) were used for the amino functionality due to their ability to form the …
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Preparation Of Oligonucleotide Delivery Agents And Insulin Depot Materials Using Solid Phase Synthesis
… oligoarginines and dendritic oligoguanidines. Solid phase techniques were used for the synthesis of these materials. The results of studies conducted on mammalian cell lines with the synthesized materials are described. Also mentioned are the problems faced during the synthesis and attempts to …
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Solution and solid-phase synthesis of potential carbohydrate vaccines for leishmaniasis and malaria
… of the parasite by host macrophages. The synthesis of a unique tetrasaccharide found on the parasite cell surface lipophosphoglycan is described. The synthetic material was used to create two novel immungens that are currently being evaluated in an animal model. New methods were also …
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
… peptides were successfully synthesized by solid phase peptide synthesis (SPPS) which was used not only for the covalent bonding of the metallocenes to the peptides but also for the complexation of platinum to the peptides and fluorescence labelling with FITC. Comprehensive characterisation …
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Solvophobically-Driven Folding of Non-Biological Oligomers and the Solid Phase Synthesis of Phenylacetylene Oligomers
The ordered sequence of monomers in phenylacetylene oligomers can serve as a repeating motif to produce helical structures in solution which posses a tubular cavity. Calculations with modest size oligomers show stable helical conformations with as few as 8 monomer units. Oligomers with triglyme …
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Solution-phase and automated solid-phase synthesis of high-mannose oligosaccharides : application to carbohydrate microarrays and biological studies
(cont.) 2G12, cyanovirin-N, and a recently identified anti-HIV protein, scytovirin.
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The Solid Phase Synthesis of M-Phenylene Ethynylene Oligomers and Its Application to the Synthesis of Covalent Molecular Ladders
With the advent of a practical solid phase synthesis of m-phenylene ethynylene oligomers their use as building blocks for the synthesis of 2D grids was attempted. In order to assess the practicality of forming large 2D grids through the use of dynamic covalent chemistry we first targeted the …
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The utilisation of Fmoc solid phase chemistry as a novel approach to the generation of duocarmycin analogues
… thesis describes the conception and multi-gram synthesis of a duocarmycin SA alkylation subunit suitably substituted to serve as a building block for Fmoc based solid phase synthesis and initial investigations into its application. Chapter two describes the pilot and subsequent large scale …
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Toward the automated synthesis of carbohydrates and glycosaminoglycans
… with most complex polysaccharides, the chemical synthesis of glycosaminoglycan structures is challenging. This thesis describes efforts towards the construction of oligosaccharides with the ultimate goal of the automated synthesis of glycosaminoglycans. The use of glycosyl phosphates of …
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The application of immobilized reagents and scavengers to multi-step organic synthesis: a total synthesis of epothilone C.
Chapter one provides an introduction to solid-phase synthesis techniques including an account of the development and integration of solid-supported reagents within multistep synthesis as a background to the project. Chapter two introduces the epothilone natural products including an explanation of …
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Fast flow biopolymer synthesis
… the development and application of fast flow solid phase synthesis for the preparation of peptides and phosphorodiamidate morpholino oligomers (PMOs), as well as the application of fast, reliable peptide synthesis to study non-natural protein folding and function. In the first chapter, solid …
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Solid-phase combinatorial chemistry and scintillation proximity assays
… in aqueous media. This thesis describes the synthesis of scintillant-tagged-compounds for application in a novel cell-based SPA. A series of 4-functianlised-2,5-diphenyloxazole molecules were synthesised. These 4-functionalised-2,5-diphenyloxazoles were evaluated by Sense Proteomic Ltd. …
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Pin1 Catalytic and WW Domain Ligands
… to discover biologically active compounds, and solid-phase synthesis is most commonly used to synthesize combinatorial libraries. To identify ligands for the Pin1 WW domain, a library, R1CO–pSer–Pro–NHR2, was designed. A new solid-phase phosphorylating reagent (SPPR) containing a phosphoramidite …
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Mg- and Zn-Mediated Synthesis of Heterocycles in Solution and on the Solid Phase
… have been prepared both in solution and on the solid phase. Alternatively, a new route to functionalized heterocyclic Grignard reagents was developed using a low-temperature halogen-magnesium exchange. Ester, amide and nitrile functions are tolerated and the resulting organomagnesium derivatives …
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Synthesis of peptide-ligand conjugates and their applications
… areas pertaining to this dissertation, (i) synthesis strategies of peptide-ligand conjugates, (ii) their applications and (iii) chemistry of ferryls were surveyed in the introduction chapter. Next, the divergent and dual divergent strategies for the synthesis of non-heme ligand-peptide …
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Design, Synthesis and Characterization of Heme-proteins: Developing Potential Catalysts for Bio-remediation
… experiments presented in this thesis make use of solid phase synthesis and site-directed mutagenesis for the synthesis and production of these enzymes and popular chromatographic techniques for their purification. The partial characterization of these proteins revealed the essential structural …
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A novel peptide QUB-2562, discovered from the skin secretion of the frog, Agalychnis annae
… annae was identified by molecular cloning. Solid-phase synthesis was applied to synthesise the novel peptide. After the synthesis, High Performance Liquid Chromatography (HPLC) and Matrix-assisted laser desorption ionisation, time-of-flight (MALDI-TOF) mass spectrometry was used to identify …
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QUB-2577: A Bioactive Peptide from Pickerel Frog (Rana palustris) Skin Secretion
… skin secretion of Rana palustris. By applying solid-phase synthesis (SPPS), the peptide was synthesised. After purification, its antimicrobial, anticancer and other biological activities were examined. The QUB-2577 was found to process broad-spectrum antimicrobial activity. It can inhitbit the …
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Conjugation of oligonucleotides for drug delivery via a linker derived from Meldrum’s acid and A capture-release method to synthesize long oligonucleotides
… For this project we aimed for the synthesis of a propargylated glycerol phosphoramidite as a 5’-end label. Incorporation of this alkyne into oligonucleotides by solid-phase synthesis will enable the capture of the full-length sequences using azido-modified magnetic beads through a …
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