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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Solid dosage forms"”.
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Fused deposition modelling three-dimensional printing of solid dosage forms
… for the design and manufacture of complex solid dosage forms with the objective of formulating personalized medicines and on-demand manufacturing. Among commercially available models, fused deposition modelling 3D-printing (FDM-3DP) has shown the potential to fabricate objects with various …
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Critical Quality Attributes of Topical Semi-solid Dosage Forms: Solvent Activity
… systems constitute a major proportion of semisolid cream type formulations and its inclusion is critical to overall product performance (drug delivery to skin). A majority of the commercially available dermatological formulations contain solvent systems (water, ethanol, propylene glycol, …
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The design and manufacture of immediate-release optimal solid dosage forms
… pharmaceutical products, immediate-release solid dosage forms, from drug substance and excipient are: blending, wet granulating, drying, milling and screening, blending, tableting, coating, and so on. A new process, such as blending combined with solvent-less, multi-component …
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Layer bonding of solvent-cast thin films for pharmaceutical solid dosage forms
… process, a batch-based process based on solid powder handling, presents challenges such as inhomogeneous blending between Active Pharmaceutical Ingredients (APIs) and excipients, low yield, and low production rate. These difficulties can be resolved by the realization of a continuous …
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Dissolution of disintegrating solid dosage forms in a modified dissolution testing apparatus 2
… industry to determine the dissolution rate of solid dosage forms. Dissolution testing serves as a surrogate for drug bioavailability through in vitro-in vivo correlation (IVIVR), and it additionally helps in guiding the development of new formulations and in assessing lot-to-lot consistency, …
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
… (HME) for the preparation of sustained release solid lipid matrices. The use of lipids instead of polymers is a novel approach with distinct advantageous. Sustained release solid lipid matrices of diclofenac sodium (Df-Na)/Compritol® 888 ATO (888 ATO) prepared using different approaches such as …
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Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms
… copolymer (Eudragit® EPO) matrix to produce solid dispersions by hot-melt extrusion processing. The obtained granules were incorporated into orally disintegrating tablets (ODTs). The tablets were developed by varying the ratio of superdisintegrants such as sodium croscarmellose and …
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Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis.
… FS30D - a pH-sensitive polymer. The described dosage forms should selectively deliver the drug to the colon through pH-dependent dissolution of the polymer coating at colonic pH conditions (pH 7.4), thereby minimising the incidence of any gastrointestinal side effects. Dissolution results …
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In-situ analysis of polymer film coats using AFM and thermal probe methods
The in-situ analysis of pharmaceutical solid dosage forms films is of great interest to pharmaceutical research, especially with the drive towards continuous processing compared to batch processing requiring either in-line or on-line analysis of pharmaceuticals. The size and shape of many solid …
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Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery
… project was to develop multi-particulate dosage forms for delivery of lactic acid bacteria: (a) the development of an oral dosage form containing a high concentration of viable, genetically modified, IL-10 producing Lactococcus lactis (b) the development of a formulation for delivery of …
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Comparison of the sutherlandioside B levels in two commercially available Sutherlandia frutescence preparations and the effect of elevated temperature and humidity on these levels
… leaves). Most of these commercial Sutherlandia solid dosage forms are made from the dried leaf powder but recently a new product, viz. Promune™ capsules, made from a freeze-dried aqueous extract, came on the market and was claimed to be “better” as it mimics the traditional tea. However, the …
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Analytical studies on diazepam
… stored samples of formulations, it was seen that solid dosage forms showed no degradation, but degradation products were detected in liquid formulations. Advantages and disadvantages were seen for both techniques and criteria were established for the choice of method. The reaction kinetics of the …
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Multi-scale analysis and simulation of powder blending in pharmaceutical manufacturing
… in the pharmaceutical manufacturing of solid dosage forms. The pharmaceutical materials investigated were anhydrous caffeine, lactose monohydrate and micro- crystalline cellulose (MCC). At the macroscopic level, blending experiments were conducted in mini-scale lab blenders using the …
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Trends in Pharmaceutical Product Development 2000-2010
… study. The emphasis of the study was on oral solid dosage forms. A combination of qualitative and quantitative methods was employed to obtain a wide view on the subject of the study. Qualitative interviews with the Finnish regulatory authorities were used to collect background information for …
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Dissolution kinetics of model api in molten polymer excipients during batch processing
… has been recently introduced to develop new solid dosage forms and products. By dissolving the poorly-soluble active pharmaceutical ingredients (API) into water-soluble polymers, the bioavailability of the Class II (with low solubility and high permeability in water) API in Biopharmaceutical …
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A Series of Pharmaceutical Technology Concepts Applied to Pediatric Formulations
… agencies in the United States and Europe. Since solid dosage forms such as tablets and capsules will not be able to improve pediatric patients’ compliance, customized pediatric formulations are needed. In response, formulators in the pharmaceutical industry have made significant effort into …
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Dissolution of different commercial aspirin tablets using a novel off-center paddle impeller (OPI) dissolution testing system
… The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this work, a modified Apparatus 2, termed "OPI" System for "off-center paddle impeller," in which the impeller is placed 8 mm off center in the vessel is …
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Comparative analysis of the dissolution performance of aspirin tablets in the usp apparatus 2 and in a minivessel dissolution system
… industry in order to ensure that the final solid dosage forms have consistent dissolution properties. Dissolution tests are also routinely conducted to evaluate the in-vitro performance of solid dosage forms during pharmaceutical development, to aid in the behavior of formulations, and to …
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Experimental investigation of the effect of sonication on the precipitation of grieseofluvin by impinging jets
… 80% of drugs on the market are manufactured as solid dosage forms, such as tablets. Drug bioavailability increases as the particle size decreases and the surface area per unit volume of drug increases. Therefore, there is a keen interest by the pharmaceutical industry to develop techniques that …
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Dissolution testing of prednisone and salicylic acid calibrator tablets at different tablet locations
… industry to determine the rate of dissolution of solid dosage forms. This test is one of the several tests that pharmaceutical companies typically conduct on oral dosage formulations (e.g., tablets) to determine compliance. The USP Dissolution Testing Apparatus 2 is the most common of the …
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