Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Solid Lipid Nanoparticles"”.
-
Development of solid lipid nanoparticles for sustained release of anticancer agents
A brief introduction to solid lipid nanoparticles (SLN) is provided and the reasoning behind the use of SLN over other colloidal carriers, such as emulsions and liposomes, are discussed. SLN has many advantageous such as controlled drug release, non-biotoxicity of the carrier, increased …
-
Synergistically active curcumin resveratrol solid lipid nanoparticles for treatment of melanoma
… and resveratrol. In this context, topical solid lipid nanoparticles were introduced as a drug carrier to enhance the skin penetration of the aforementioned polyphenols and exploit their anti-cancer activity. Small, negatively charged curcumin and resveratrol loaded SLNs (Cur-Res SLNs) with …
-
Design and Development of Solid Lipid Nanoparticles for Ocular Delivery of Acyclovir
… of acyclovir (ACV) by incorporating it into solid lipid nanoparticles (SLNs) and nano-structured lipid carriers (NLCs). Methods: SLNs and NLCs were prepared by a hot microemulsion technique. Nanoparticles were characterised by laser diffraction size measurements, zeta potential, scanning …
-
RGD-targeted Solid Lipid Nanoparticles Containing Asiatic Acid for the Treatment of Cancer
… promising therapeutic applications for many solid tumours. Active targeting of DDSs relies on specific interactions between the ligand (generally conjugated onto the surface of DDSs) and its receptor, which is overexpressed on target tumour tissues. In this study, arginine-glycine-aspartic …
-
Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… treatment of prostatic carcinoma. FLT amorphous solid dispersions (SDs) and solid lipid nanoparticles (SLNs) were prepared to overcome limited solubility. Investigation of drug-polymer and drug-lipid miscibility was carried out to enhance drug performance by assessing solubility and particle …
-
Lipid & surfactant based systems for improved delivery of poorly soluble APIs
… and low plasma levels post oral administration. Lipids comprise of fatty acids and their derivatives and are considered a biocompatible option for drug delivery. In the studies discussed in following chapters, lipid based drug delivery systems (LBDDS) have been utilized in improving the handling, …
-
Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines.
… has been successfully encapsulated within solid lipid nanoparticles and a comparative cytotoxicity study was performed using MTT assay. After a 24-hour treatment, the 3 compounds alone demonstrated a strong cytotoxicity with IC50 values ranging from 1.3 to 2.6 μM in both SW620 and SW480. …
-
Hot-melt extrusion: A versatile pharmaceutical technology
… a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure …
-
Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye
Lipid based systems and topical ocular inserts of various drugs were developed for the intervention/treatment of posterior segment ocular complications. Indomethacin (IN) was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface …
-
Biopharmaceutical approaches for improved drug delivery across ocular barriers
… and formulation approaches (cyclodextrins and solid lipid nanoparticles (SLNs)) were evaluated in terms of their ability to improve the ocular bioavailability of hydrophilic and lipophilic compounds, respectively. A novel approach, localized modulation of RPE P-gp using topically …
-
Development and Characterization of a Topical Ocular Delivery System for Hydrogen Sulfide for the Treatment of Glaucoma
… index. Therefore, this study developed a novel lipid-based delivery system for Diallyl Trisulfide (DATS), a H2S donor, to provide sustained release of H2S up to 8-9 hours upon topical application on the cornea. A high-performance liquid chromatography (HPLC) method was developed and validated as …
-
Solid Lipid Nanoparticulate Formulation for ifosfamide: Development and Characterization
… its stability and sustaining in vitro release. Solid lipid nanoparticles (SLNs) of ifosfamide were developed by double emulsion solvent evaporation technique using glyceryl monooleate and chitosan. The chitosan present in the delivery system was cross-linked using sodium tripolyphosphate. The …
-
Investigating alternative delivery systems for self-Amplifying RNA vaccines
… cationic nano emulsions (CNE), polymeric nanoparticles (NPs), lipid nanoparticles (SLNs) and liposomes were formulated in the absence of or in combination with a specific SAM vaccine. Despite the differences in formulation composition, all samples contained the same concentration of …
-
Surface Modified Solid Lipid Curcumin Nanoparticles For Oral Delivery
… for its use as a chemotherapeutic agent. Solid lipid nanoparticulate formulations have been successfully used to enhance the oral bioavailability of several poorly soluble drugs. The objective of the present research was to develop and characterize solid lipid nanoparticles for oral …
-
Multifunctional Nanoparticles for Cancer Therapy
… present study was to develop and characterize nanoparticles containing two anticancer agents having different mechanisms of action that would target both differentiated as well as cancer stem cells. The two hydrophobic antitumor agents (cyclopamine and paclitaxel) were entrapped in glyceryl …
-
EVALUATION OF PHARMACEUTICAL AND COSMETIC USE OF EXCIPIENTS OBTAINED FROM CITRUS PROCESSING WASTE PRODUCTS
… can be further used to recover residual lipid traces that have not been investigated so far. This doctoral thesis aimed to investigate whether bergamot lipid components (BLCs) remaining in the bergamot discarded biomass could be a functional excipient for the preparation of dosage forms …
-
Novel sustained release formulation of leveodopa-dendrimer conjugate
… was further used to prepare surface modified solid lipid nanoparticles. The conjugate was added to the lipid phase made up of Glyceryl monooleate (GMO) and oleic acid. Tween 80 was used as the emulsifying agent having a HLB value of around 13. Tween 80 was used due to its reported property of …
-
Non-invasive drug delivery to the posterior segment of the eye: Development of formulation strategies and evaluation of ocular distribution and pharmacological activity
… upto 6 h. We also prepared HT loaded (0.1% w/v) solid lipid nanoparticles (SLN’s) using a combination of 85% glyceryl monostereate and 15% compritol ATO 888. The particle size, zeta potential and entrapment efficiency of the HT-SLN’s was 225 nm, -21 mV and 85% respectively. Although the dose …
Page 1 of 2