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Showing 1 to 7 of 7 for “"Sodium/iodide symporter"”.
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SODIUM/IODIDE SYMPORTER-NIS Abundant and Important in Gastric Mucosa
… in thyroid hormones. Biological mechanisms for iodide uptake and concentration are very important, espe-cially as iodine is a relatively scarce element. Active iodide transport into thyroid fol-licular cells is mediated by the sodium/iodide symporter (NIS), powered by Na+/K+-ATPase. NIS is …
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Application of radioisotope imaging and therapy in patients with breast carcinomas that express the sodium iodide symporter gene
Aims The Sodium Iodide Symporter (NIS), which is located in the basolateral membrane of the thyroid follicular cell, catalyses an active transport mechanism allowing Iodide, an essential component of the thyroid hormones Tri-iodothyronine(T3) and Thyroxine(T4), to accumulate in the thyroid gland. …
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Der humane Natrium-Jodid-Symporter (hNIS) : Entwicklung einer Methode zur Quantifizierung der hNIS-mRNA-Expression und Analyse der Rolle als Antigen bei autoimmunen Schilddrüsenerkrankungen
The human sodium-iodide-symporter (hNIS) is the key molecule for iodide uptake into the thyroid gland. Iodide is essential for the biosynthesis of the thyroid hormones T3 and T4. The symporter is localized at the basolateral membrane of thyroid follicular cells and transports iodide against its …
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Development of a novel imaging system for cell therapy in the brain.
… a non-invasive imaging technique using the human sodium-iodide symporter (NIS) as a reporter gene system for in vivo imaging of neural stem cells in the brain. My data show that the NIS, in combination with SPECT/CT imaging, allows for the repeated visualization of neural stem cells in vivo, and …
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Molecular imaging of gene transduction in cardiac transplantation
… feasibility of visualizing the presence of the sodium iodide symporter (hNIS) non-invasively following its gene transduction was established with the use of SPECT imaging. Following gene transfer, the recipients were injected with ⁹⁹mTc in the first set of experiments (Chapter 3) or with …
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Effects of ammonium perchlorate exposure on the thyroid function and the expression of thyroid-responsive genes in Japanese quail embryos and post hatch chicks
… thyroid function by competitively inhibiting the sodium-iodide symporter, thus blocking iodide uptake into the thyroid gland. In this study, the effect of perchlorate exposure on thyroid function and thyroid-responsive gene expression were examined in (1) embryos from eggs laid by …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… that were genetically modified with the human sodium iodide symporter gene (hNIS; SLC5A5) for the purpose of tumor imaging. Lung tumor growth was quantified using single-photon emission computer tomography (SPECT) and computed tomography (CT) imaging. hNIS is a membrane glycoprotein that …