Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"SodC"”.
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Superoxide Toxicity in Escherichia Coli
… occurs there. We studied the regulation of sodC, the gene that encodes CuZnSOD, and the phenotypes of sodC mutants to determine its physiological role. We found that sodC is activated by RpoS in stationary phase, is repressed by Fnr and ArcA anaerobically, and is repressed when copper is …
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Survival of Salmonella in the macrophage phagosome
… within the Salmonella containing vacuole. SodCI, a periplasmic superoxide dismutase, is required to defend Salmonella against phagocytic superoxide. Work from our lab and others has established that SodCI functions to defend an extracytoplasmic target from the oxidative burst. The work …
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Genetic and Immunological Analyses of a Brucella abortus Protein Exhibiting Lectin-like Properties
… strain RB51 was achieved using Brucella groE and sodC promoters as well as its own promoter. Protection and clearance studies were performed in mice to determine the role of this protein in Brucella immunity and pathogenesis. Inoculation with either strain RB51 overexpressing the 16 kDa protein or …
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Analyse des Transkriptionsprofils von Neisseria meningitidis während der Infektion von Epithel- und Endothelzellen unter Verwendung der Mikroarraytechnologie
… Dazu gehören die Virulenz assoziierten Gene sodC, iga und nadA sowie das für ein Hämolysin kodierende Gen NMB1779. Die Untersuchung des Expressionsprofils mittels SDS-PAGE Analyse führte zur Identifizierung einer Proteinbande bei 210 kDa, die spezifisch für die NMB1843 negativen Stämme ist. …
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Regulation of virulence in Salmonella enterica
… produces two periplasmic superoxide dismutases, SodCI and SodCII, but only SodCI contributes to virulence. Although we have shown that this is primarily due to differences in the two proteins, evidence suggested that the two genes are differentially regulated. Part of this thesis describes sodCI …
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Antimicrobial Effectors Act Cooperatively to Stress Salmonella in the Macrophage Phagosome
… two Cu-Zn periplasmic superoxide dismutases, SodCI and SodCII. Although both enzymes are expressed during infection, only SodCI contributes to virulence in the mouse by combating phagocytic superoxide. We have shown that the differential contribution to virulence is due to inherent differences …