Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Social defeat"”.
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Social defeat and oxytocin regulation of social avoidance and stress-related signaling proteins
Social anxiety disorder (SAD) is one of the most common and disabling anxiety disorders. SAD is characterized by generalized social avoidance and high comorbidity with other psychiatric disorders. Despite its adverse prognosis, the molecular mechanism underlying this condition and its high …
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Vulnerability and Resilience to Social Defeat: The Role of Neuroplasticity Within the Mesolimbic Dopamine Circuit
… that an inbred population of mice subjected to social defeat can be separated into susceptible and unsusceptible subpopulations which differ along several behavioral and physiological domains. Through a series of molecular and electrophysiological techniques, we identify signature adaptations …
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Role of Oxidative Stress in Behavioral, Cognitive and Biochemical Impairment in a Rat Model of Social Stress
… oxidative stress (OS) in psychological stress (social defeat)-induced behavioral and cognitive impairments in rats. Basically, psychological stress induces behavioral and cognitive deficits in rats while increasing oxidative stress systemically as well as in the brain. Increase in oxidative …
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Regulation of Adult Hippocampal Neurogenesis: Insights from Mouse Models of Dementia and Depression
… Finally, I look at changes in neurogenesis in a social-defeat depression model. I find that, like other models of repeated stress, social-defeat stress appears to produce a stress-induced decrease in S-phase cells. However, closer analysis reveals that this decrease does not indicate decreased …
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THE EFFECTS OF SOCIAL STRESS AND PRIOR ETHANOL EXPOSURE ON DOPAMINE IN THE RAT BRAIN
… cyclic voltammetry to examine the effects of social defeat stress and chronic ethanol exposure on ethanol-induced dopamine changes in key structures of these two dopaminergic pathways, the nucleus accumbens core and dorsolateral striatum. Experiments revealed an effect of stress through …
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The Role of DNA Methylation in Addiction and Depression
… reward region, by chronic cocaine or chronic social defeat stress. Moreover, NAc specific manipulations that block DNA methylation potentiate cocaine reward and exert antidepressant-like effects, whereas NAc specific Dnmt3a overexpression attenuates cocaine reward and is pro-depressant. On a …
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Analysis of the behavioural effects of barley and sertraline in two in-vivo models of stress.Anti-depressant and anti-nociceptive effects of barley in mice and sertraline effects on anxiety in the offspring of prenatally-stressed rats
… 58 reserpinised, 56 non-reserpinised) and Social ‘Defeat’ Test (n=24, 8 vehicle undefeated, 8 barley defeated, 8 vehicle defeated mice). To confirm that the anti-depressant effects of barley(6.4g/kg) were not simply due to increased locomotor activity in the FST, an Open Field Test(OFT) was …
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Analysis of the behavioural effects of barley and sertraline in two in-vivo models of stress.Anti-depressant and anti-nociceptive effects of barley in mice and sertraline effects on anxiety in the offspring of prenatally-stressed rats
… 58 reserpinised, 56 non-reserpinised) and Social ‘Defeat’ Test (n=24, 8 vehicle undefeated, 8 barley defeated, 8 vehicle defeated mice). To confirm that the anti-depressant effects of barley(6.4g/kg) were not simply due to increased locomotor activity in the FST, an Open Field Test(OFT) was …
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Stress, Monoamines, and Cognitive Flexibility
… to facilitation of reversal learning in a defeat-resistant subpopulation of rats exposed to social stress, underscoring the importance of stress history and coping strategy in determining the impact of stress. Finally, adolescent social stress produced an enduring impairment of cognitive …
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Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
… KI mice and their WT littermates through chronic social defeat stress, a behavioral paradigm in which repeated exposure to aggressive mice causes social avoidance that is reversed by chronic but not acute antidepressant treatment. Although the WT mice show an increase in social interaction …
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Impact of adult hippocampal neurogenesis on behavior
… hippocampal neurogenesis (x-irradiation and social defeat). We find that levels of reactivation in CA3, both in the presence and in the absence of neurogenesis, are correlated with the strength of the memory, which suggests that the cells reactivated in CA3, are a component of the memory …