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Showing 1 to 2 of 2 for “"Snl1"”.
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Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast
… counterparts; Sse1/Sse2/HSP110, Fes1/HspBP1, and Snl1/Bag1. In an effort to understand the differential functional contributions of the cytosolic NEFs to protein homeostasis (“proteostasis”), I carried out comparative genetic, biochemical and cell biological analyses. For these studies, I …
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Biochemical Characterization of Binding Partners of Two Hsp70 Co-Chaperones In Saccharomyces Cerevisiae
… are present: Sse1 (Hsp110), Fes1 (HspBP1) and Snl1 (Bag-1). Snl1 is unique among the cytosolic NEFs as it is localized at the ER membrane with its Hsp70 binding (BAG) domain exposed to the cytosol. I discovered that Snl1 distinctly interacts with assembled ribosomes and several lines of …