Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"Smooth muscle cell"”.
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… which shows increased activation in vascular smooth muscle cells (VSMCs) of advanced atherosclerotic plaques, specifically within the intimal layer. Since VSMC apoptosis plays a crucial role in the pathophysiology of atherosclerosis, we investigated the mechanisms underlying FOXO3a-mediated …
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RHAMM Alters Vascular Smooth Muscle Cell Constrictive Matrix Remodeling
… in this dissertation was to determine whether smooth muscle cell (SMC) interactions with hyaluronan (HA) mediated by the receptor for hyaluronan-mediated motility (RHAMM), affects arterial SMC adhesion, migration and collagen matrix remodeling in vitro as well as constrictive remodeling …
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… Recent research using lineage tracing and single-cell RNA sequencing unveiled a previously undescribed and prominent role of smooth muscle cells (SMCs) in atherosclerotic plaque formation. SMCs undergo complex phenotypic modulation characterized by de-differentiation of SMCs and heterogeneously …
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
… the United States and worldwide. Localized extracellular acidosis has been theorized as a possible contributor to CVD pathogenesis, but its precise impact remains unclear. G protein coupled receptors (GPCRs) are seven transmembrane receptors that have wide-ranging functions in cardiovascular …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
… studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to mechanical stimuli. VSMC differentiation is a crucial developmental process regulating angiogenesis and vasculogenesis, with phenotypic modulation of SMC …
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Regulation of vascular smooth muscle cell function by mechanical strain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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Endothelial cell impact on smooth muscle cell properties: role of hemodynamic forces
The vascular endothelium is a dynamic cell monolayer located at the interface of the vessel wall and bloodstream, where it regulates the physiological effects of humoral and hemodynamic stimuli on vessel tone and remodelling. Hemodynamic forces are of particular interest and include shear stress, …
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease remain unresolved. In particular, it is not known if all VSMCs …
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A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
Vascular smooth muscle cells (VSMCs) possess a remarkable capacity to change phenotype in response to injury or inflammation. In healthy arteries, VSMCs exist in a contractile state, but upon vascular inflammation or injury, they can switch into an activated state, in which they downregulate the …
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THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS
… all’età, caratterizzata dall’accumulo di cellule senescenti, in particolare di cellule muscolari lisce vascolari (VSMC). Queste cellule, pur mantenendo un’attività metabolica, mostrano importanti alterazioni morfologiche, disfunzioni mitocondriali e adottano un fenotipo secretorio …
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MATHEMATICAL MODELLING OF CALCIUM DEPENDENT ACTIVE CONTRACTION IN A GASTROINTESTINAL SMOOTH MUSCLE CELL
… model to study the relationship between intracellular calcium concentration and active contraction in gastric smooth muscle cells has been developed. Gastric motility is brought about by the co-ordinated contraction and relaxation of the smooth muscle. First, contraction triggered by calcium …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
Phenotypic plasticity of human arterial smooth muscle cells (HASMCs) allows them to transition from a “contractile/quiescent” state, in which they regulate arterial tone and blood pressure, to one in which these cells are more “synthetic/activated”. Synthetic/activated HASMCs are migratory and …
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Effects of The Acta2 R258C Mutation On Vascular Smooth Muscle Cell Phenotype and Properties
… in these families is <em>ACTA2</em>, encoding smooth muscle-specific α-actin. <em>ACTA2</em> missense mutations predispose individuals both to TAAD and to vascular occlusive disease of small, muscular arteries.</p> <p>Mice carrying an <em>Acta2 </em>R258C mutant transgene with a wildtype …
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Integrin alpha(v) and Focal adhesion kinase - promising targets to limit smooth muscle cell migration
Die Prävention einer Restenose nach PTCA ist eines der wichtigsten Ziele für Forscher und Kliniker. Etwa 1,5 Millionen Interventionen werden weltweit jährlich durchgeführt und mit Hilfe von Stentimplantationen können die meisten Patienten erfolgreich behandelt werden. Jedoch kommt es in bis zu 60 % …
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The Role of Dna Methylation and Hydroxymethylation In Smooth Muscle Cell Phenotypic Change During Atherogenesis
… atherogenesis, lipid deposits, inflammation, and cells accumulate within the walls of arteries, ultimately leading to a buildup of fatty plaques and occlusion of the arterial lumen. In a multifactorial disease like atherosclerosis there are complex interplays between environmental, genetic and …
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