Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Smarcb1"”.
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SMARCB1 Maintains Lineage Fidelity in Clear Cell Renal Cell Carcinoma
… and in vivo validation I show that the loss of SMARCB1, a member of the SWI/SNF chromatin remodelling complex, confers an advantage to ccRCC cells upon inhibition of the essential renal lineage factor PAX8. SMARCB1 knockout (KO) leads to large-scale loss of a kidney-specific enhancer program, …
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Understanding The Pathogenesis of Renal Medullary Carcinoma
… also demonstrated in cell culture studies that SMARCB1 is ubiquitinated for proteasome-mediated degradation in hypoxia, and the re-expression of SMARCB1 leads to compromised proliferation in renal cells specifically in the context of hypoxia. Overall, we proposed that the link between SCT and …
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Genetic interactors of the SWI/SNF chromatin remodelling complex in Caenorhabditis elegans
… mutation in the SWI/SNF core subunit snfc-5 (SMARCB1 in humans) can prevent embryonic lethality in animals harbouring the loss-of-function mutation in the SWI/SNF core subunit swsn-1. Secondly, I found that the combination of this specific mutation in snfc-5 and a loss-of-function mutation in …
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STUDY OF PHYSIO-PATHOLOGICAL MECHANISMS AT THE BASE OF SCHWANNOMA DEVELOPMENT
… NF2 gene, although recently other mutations in SMARCB1 and LZTR1 genes were found. Considerable overlap has been found between SCH and NF2, in terms of the occurrence of associated types of tumors, whereas both diseases are considered as separated clinical entities. Therefore, it is not excluded …