Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Smarca5"”.
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The roles of DPPA2, DPPA4 and SMARCA5 in mouse zygotic genome activation, epigenetic reprogramming and development
… DPPA2, DPPA4 and the chromatin remodeler SMARCA5 as potential inducers of major ZGA. Here I focus on validating these three factors and I assess their roles in vivo, using conditional knock-out mouse models and a targeted protein depletion system, together with the characterisation of the …
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LINKING CHROMATIN REMODELING TO MITOCHONDRIAL DYSFUNCTION: A ROLE FOR THE SMARCA5-MYC-TFAM AXIS IN HEPATOCELLULAR CARCINOMA
… novel mitochondrial regulators identified Smarca5 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 5), an ATP-dependent chromatin remodeler of the ISWI family, as essential gene for maintaining mitochondrial function, proliferation, and …
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CRISPR activation screening at single-cell transcriptomic resolution: discovering new regulators of zygotic genome activation
… binding protein Dppa2, the chromatin remodeller Smarca5 and the transcription factor Patz1. I subsequently validate these top hits using both CRISPRa and cDNA overexpression in mESCs. By doing this, I uncover new factors that promote a ZGA-like response in mESCs and are, therefore, strong …
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Regulation of the Kcnq1ot1 Imprinting Domain in Mouse
… (RNAi) screen. Depletion of candidates Ezh1, Smarca5 and Smarcad1 resulted in loss of imprinted expression of Cdkn1c and Kcnq1 but not Osbpl5 and Slc22a18, suggesting epigenetic modifiers identified here function at genes proximal to the Kcnq1ot1 ICR and not domain-wide. Kcnq1ot1 expression …