Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Small-molecule synthesis"”.
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Expanding automated modular small molecule synthesis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Phosphate Tether-Mediated, One-Pot Metathesis Processes: Application in Small Molecule Synthesis
… to mediate a series of reactions towards the synthesis of bioactive molecules by exploiting several salient features inherent to organophosphates, including (i) orthogonal stability under acid conditions, (ii) possessing leaving group ability, (iii) multivalent activation of carbinol centers, …
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Multivalent activation in temporary phosphate tethers: A new tether for small molecule synthesis
… these selective cleavage reactions towards the synthesis of non-phosphorus polyketide fragments was further shown. With the methodology in place, we turned our attention towards the synthesis of the C1-C15 fragment of the dolabelide family of macrolides. Two routes were realized, both taking …
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Stereoselective synthesis and iterative coupling of Csp3 boronates for automating small molecule synthesis
Small molecules perform many important functions in nature, medicine, and technology. However, efforts to discover and optimize new small molecule function are often impeded by limitations in synthetic access to this class of compounds. In contrast to peptide and oligonucleotide syntheses, small …
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Automated small molecule synthesis for accelerated discovery of photo- and electroactive organic materials
… the photostability of light-harvesting organic molecules with donor–acceptor structures. CLT identified critical mechanistic factors such as the role of high-energy triplet state manifolds via automated modular synthesis and characterization of only ~1.5% of the theoretical molecular space. This …
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Towards the automation of small molecule synthesis: The development of an impact-prioritized list couplings and blocks for building block assembly of most linear natural products
… preparation of functionally important organic small molecules can be exceptionally impactful. Identification of such methods has traditionally been done on an ad hoc basis and largely driven by the goal of enabling a customized approach to each target structure. Here we report an en masse …
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Iterative cross-coupling with MIDA boronates
Many small molecules targeted for synthesis in the laboratory are inherently modular in their construction. Harnessing this modularity towards a unified strategy for the synthesis of these compounds, this dissertation describes an approach to small molecule making based on the iterative …
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Expansion of the iterative cross-coupling synthesis strategy through Csp3 halide cross-coupling, Mida boronate synthesis, and chan-lam couplings
The iterative cross-coupling strategy for small molecule synthesis has been shown to be a powerful and effective method for the synthesis of small molecules. However, this strategy was limited by current methodological limitations. Therefore, we have extended the power and application of the …
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Design of a second generation MIDA boronate: iterating c(sp3) based Suzuki cross couplings
Small molecules have had a tremendous positive impact on human health and society in general. Despite this, small molecule synthesis is still a time and cost intensive process practiced primarily by highly trained specialists. Inspired by the impact of general, automated synthesis platforms for …
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A small molecule synthesizer
… many advances over the last two centuries, small molecule synthesis remains a relatively complex, unsystematized, and time-intensive process practiced almost exclusively by highly trained specialists. Collectively, these limitations represent a major bottleneck in the efforts to study, …
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Modular synthesis for cooperative small molecule ligands and chemical education
Modular synthesis can be leveraged as both a synthetic strategy for accessing cooperatively binding small molecule ligands as well as a pedagogic framework for chemical education. Mimicking hemoglobin’s cooperative binding to oxygen stands as an unclimbed mountain in the field of protein mimicry …
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Part I: synthesis and cross-coupling of the C1-C12 primary organoborane building block of amphotericin B; Part II: site- and stereoretentive cross-coupling of unactivated secondary boronic acids inspired by amphotericin B
… fashion from pre-fabricated building blocks, the synthesis of small molecules has remained a relatively slow, complex, and unsystematized process. With the potential of addressing these limitations, an analogous building block-based approach for making small molecules has been proposed in our …
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Synthesis and function of the conserved motif of mycosamine-containing polyene macrolides
… through ion channel formation and thus represent small molecules with the capacity to perform a protein-like function. This function and the dose-limiting toxicity of AmB are thought to be dependent upon the presence of sterols in the cellular membrane, but the precise role of sterols in this …
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Less toxic yet still resistance evasive amphotericins and atomistic probing of the amphotericin B ion channel
… impact on global human health. Similar to most small molecule medicines, AmB exerts its antifungal activity by binding and disabling a specific molecular target. In contrast, some diseases are caused by the malfunctioning of proteins, and thus lie outside this traditional paradigm. For example, …
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Closed-loop iterative molecular discovery engines
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01