Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 862 for “"Small molecules"”.
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Small Molecules Binding to Serpins
Serpins are a unique breed of proteins due to their enzymatic mechanism. Two systems were closely monitored during fluorescent binding studies, the ACT-CHY along with the AT:TRY interaction. Four different conformational variants of each system were studied including the native, cleaved, latent and …
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Photodissociation Dynamics of Small Molecules
Energy disposal into CN (product) degrees-of-freedom following photolysis of BrCN and NC=CN (cyanogen) upon absorption of a single 193 nm photon was investigated. Supersonic expansion in a molecular beam was utilized to obtain a narrow distribution of initial parent states. Laser induced …
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Diffusion of Small Molecules in Solution
Made available in DSpace on 2014-12-05T19:38:13Z (GMT). No. of bitstreams: 1 6305086.pdf: 1796931 bytes, checksum: 91c64248f6cbbee7e2efc2fe3d5e9519 (MD5) Previous issue date: 1963
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Spectroscopic and theoretical studies of small molecules.
This thesis is concerned with two contrasting molecules - ketene (H2CCO) and methylene chloride (CH2CI2). High resolution (~0.05cm-1) infrared studies of ketene were carried out and complete analyses performed to the A1 species vibrations v1-v4, allowing the determination of revised vibrational …
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G-quadruplex recognition and isolation with small molecules
… but they have stimulated a lot of research into small molecules that interact with them. The development of a new class of such molecules is described in this thesis. A member of this family showed to be very selective in stabilising one particular G-quadruplex. The further development of another …
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Synthesis and antibacterial evaluation of diverse small molecules
… generate molecular diversity and complexity in small molecule screening collections. We then study a family of potential biofilm inhibitors identified from a diverse screening collection, and for which we suggest a possible mode of action upon the quorum sensing receptors LasR and RhlR. …
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Photo- and collision-induced processes in small molecules
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1988
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Towards Sustainable Electrosynthesis of Industrially Valuable Small Molecules
The decarbonization of legacy industrial processes calls for substantial advances in our ability to apply sustainably generated electricity as a means of making and breaking arbitrary chemical bonds. The development of such carbon-neutral systems demands the design of efficient and selective …
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Adsorption of Small Molecules in Advanced Material Systems
… In this dissertation, the adsorption of small molecules in three emerging materials systems: porous liquids, room-temperature ionic liquids, and atomically sharp electrodes immersed in aqueous electrolytes, are investigated to understand the physics of adsorption as well as to help design …
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Stereochemistry of small molecules: Configurational and conformational control
… the relative spatial arrangement of atoms within molecules (static stereochemistry), and the study of the stereochemical requirements and outcomes of chemical reactions (dynamic stereochemistry). These two branches complement each other in modern stereochemistry. Chiral organometallics feature …
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Development of Main Group Systems for Small Molecules Activation
… has found diverse applications in areas such as small molecules activation and catalysis. The present thesis has two major directions: 1) find new types of FLP; 2) demonstrate their unusual reactivity. Alkali metal species are shown to mimic FLP behavior. The combinations of Lewis acidic alkali …
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Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
… states and conformations through the use of small molecules could be a powerful therapeutic strategy that targets toxicity regardless of other factors involved in the formation of tau oligomeric strains. Herein, I used biochemical and biophysical in vitro techniques to characterize preformed …
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Novel small molecules for modulation of bacterial signaling pathways
… novel QS inhibitors based on common QS signaling molecules, such as N-acylated L-homoserine lactones (AHLs), indoles, N-acetyl glucosamine and other heterocyclic systems derived from halogenated furanones (Fimbrolides). Indole and glucosamine-based amides and oxo-amides were synthesized as …
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… part of the project was aimed at identifying small molecules exerting a mitogenic effect on neonatal cardiomyocytes through an unbiased high-throughput screening (HTS) of a library of 780 FDA-registered drugs. The neuroactive alkaloid harmine was identified as the most powerful molecule at …
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Small molecules with anti-trypanosomal and anti-leishmanial activity
… study focused on the identification of novel small molecular inhibitors with anti-parasitic activities against Trypanosoma brucei spp. (HAT), Trypanosoma cruzi spp. (Chagas disease) and Leishmania infantum spp. (Leishmaniasis) with a particular focus on combining broadspectrum activity with …
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The use of small molecules to illuminate vascular development
… patterning, and its stability. I have used small molecules to probe these processes. First, I showed the advantage of using zebrafish as a model system for efficiently screening anti-angiogenic small molecule compounds designed for cancer therapy. Treating cancer by inhibiting its …
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Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules
… on identification, design and synthesis of small molecules that effectively induce death in various cancers by activating the apoptotic cascade. Described herein is discovery of anticancer small molecules that selectively induce cell death in white blood cancers and non-toxic to other cell …
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RNA recognition: controlling RNA-protein complexes with small molecules
ABSTRACT PART I. Investigation of Small Molecule Binding to an RNA Hairpin Loop Containing a Dangling End PART II. Unraveling the Interaction of Pathogenic RNAs with the MBNL1 Protein and Complex Inhibition by Small Molecules PART I. RNA plays important and versatile roles in gene expression by …
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Computational analyses of small molecules activity from phenotypic screens
Drug discovery is no longer relying on the one gene-one disease paradigm nor on target-based screening alone to discover new drugs. Phenotypic-based screening is regaining momentum to discover new compounds since those assays provide an environment closer to the physiological state of the disease …
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Dynamic nuclear polarization of amorphous and crystalline small molecules
Solid-state NMR has emerged to become an important technique in the studies of pharmaceutical formulations consisting of active pharmaceutical ingredients (API) and excipients. Dynamic nuclear polarization (DNP), which improves NMR sensitivity by 2-3 orders of magnitude, can potentially reduce the …
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