Global ETD Search
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Showing 1 to 10 of 10 for “"Small diameter vascular grafts"”.
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Hyaluronic acid enhancement of expanded polytetrafluoroethylene for small diameter vascular grafts
Cardiovascular disease is the leading cause of mortality and morbidity in the United States and other developed countries. In the United States alone, 8 million people are diagnosed with peripheral arterial disease per year and over 250,000 patients have coronary bypass surgery each year. …
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Near-Field Electrospinning and Characterization of Biodegradable Small Diameter Vascular Grafts
<p>The ideal “off the shelf” tissue engineering, small-diameter (< 6 mm inner diameter (ID)) vascular graft hinges on designing a template that facilitates transmural ingrowth of capillaries to regenerate an endothelized neointimal surface. Previous traditionally electrospun (TES) approaches to …
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In vitro endothelialization of vascular prostheses: a possible means to improve the early patency of small diameter vascular grafts
… unsatisfying performance of synthetic arterial grafts, we attempted to create an endothelium on the prosthetic surface by lining the graft with cultured endothelial cells. To provide sufficient cell-numbers for lining, a rapid and reliable harvest technique had to be developed first. In an …
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The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models
There is a significant need for small diameter vascular grafts to be used in peripheral vascular surgery; however autologous grafts are not always available, synthetic grafts perform poorly and allografts and xenografts degenerate, dilate and calcify after implantation. We hypothesized that …
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Extrusion and evaluation of degradation rate and porosity of small diameter collagen tubes
The limited availability of autografts and failure of small diameter synthetic vascular grafts has stimulated continuing efforts to develop small diameter vascular grafts based on natural materials. The small diameter collagen tubes were extruded using bovine collagen type I. The biodegradation …
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From developmental biology to tissue-engineering: printing blood vessels
Cardiovascular disease is a leading cause of death and often requires vascular reconstruction. However, the use of synthetic materials and scaffold-based approaches has shown several limitations for small-diameter blood vessel tissue-engineering, evidenced by the fact that they can elicit adverse …
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Coaxially electrospun heparin-eluting scaffolds for vascular graft application
The use of electrospun scaffolds for small diameter vascular grafts (< 6 mm) has shown promise in the search for alternative solutions, as current synthetic grafts have high failure rates. The inclusion of heparin into such scaffolds can be beneficial for vascular graft applications as it could …
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The mechanical design aspects of a small diameter vascular prosthesis
Failure of medium to small diameter vascular grafts is believed to be in part due to the compliance mismatch between the native artery and the implanted graft. Consequently, designers are examining the use of more compliant materials for their manufacture. Ether free polyurethanes are currently …
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Modulation of Endothelial Cell Adhesion to Synthetic Vascular Grafts Using Biotinylated Fibronectin in a Dual Ligand Protein System
… the use of substitutes. Unfortunately, synthetic small diameter vascular grafts have unacceptable patency rates, primarily due to lumenal thrombus formation and intimal thickening. Endothelial cells (EC) mediate the anti-thrombotic activity in healthy blood vessels, and due to the scarcity of …
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Stimulating angiogenesis into biomaterials through the delivery of growth factors
… materials such as ePTFE. Long term patency of small diameter vascular grafts used for infra-inguinal reconstructions, however, is below 50 % 5 years after implantation. Therefore, novel vascular graft concepts and materials are needed. The concept of transmural in vivo endothelialisation of …