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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Small Molecule Activation"”.
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Small Molecule Activation Using Transfer Hydrogenation Catalysts
Though 1 is not Lewis acidic and does not readily react with H2, the addition of a catalytic amount of acid was found to promote the hydrogenation of 1 to 1H(H). The rate of hydrogenation of 1 was found to be dependent on the identity of the acid. It was found that acids with a pKa three orders of …
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Ligand Cooperative Iridium PCP Complexes for Small Molecule Activation
Simple small molecules are perhaps the most fundamental components to synthetic chemistry, acting as the building blocks from which larger, more complex compounds are made. These simple molecules are also important in of themselves, sometimes as fuels, greenhouse gases, the water we drink, or the …
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Harnessing Aluminum Radicals via Heterobimetallic Complexes for Small-molecule Activation
… generation of “masked” Al(II) species capable of small-molecule activation. These systems exhibit diverse and controllable behavior, including proton-coupled electron transfer (PCET) processes for activating strong bonds in molecules such as water and ammonia, switchable two-electron frustrated …
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Metal-containing and Metal-free systems for small molecule activation
The objective of this thesis is to investigate small molecule activation with metal-containing and metal-free systems. Chapter 2 describes a tri-aryl benzene ligand scaffold for multimetallic N2 activation. A RuCp* complex was synthesized and characterized by NMR and X-ray crystallography. It …
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Small molecule activation and reduction using non-heme iron complexes
… advantage of biphasic solutions to avoid the deactivation of the iron catalyst. While neither oxyanion was able to be reduced catalytically with high turnover numbers or rates, this is the first homogeneous synthetic system to catalyze these reductions. Additionally, the selenium(0) produced …
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Small-molecule activation chemistry catalyzed by proton-coupled electron transfer
… at a molecular level in a broad spectrum of small-molecule activation reactions for the first time. Two distinct structural scaffolds have been elaborated to study the PCET chemistry of 0-0 bond forming and cleaving reactions. The first consists of platforms containing two redox sites linked …
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Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
<p>Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent, non-toxic, and reversible inhibitor of Hippo signaling. An ATP-competitive …
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Rigid Ruthenium PCcarbeneP Complexes for Small Molecule Activation, Hydrogenation, and Dehydrogenation
Small molecule activation is of fundamental importance to the development of catalysts for producing alternative fuels and other value-added products from abundant feedstocks. The capture and subsequent conversion of pollutant molecules like carbon dioxide and nitrous oxide can reduce their …
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Bio-inspired first-row transition metal complexes for small molecule activation
… within the secondary coordination 2) facilitate activation of molecules such as O2, NO2- and NO3- 3) catalytically reduce nitrogen-containing oxyanions. In the case of the latter, mechanistic studies have been performed to understand the role of the secondary coordination sphere, revealing its …
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Proton-coupled electron transfer : from basic principles to small molecule activation
Proton-coupled electron transfer (PCET) is the basic mechanism for bioenergetic conversion. Hallmark examples of such reactivities include water oxidation which is coupled to photosynthesis and oxygen reduction which is coupled to ATP generation by respiration. These two complementary energy …
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Cages and Guests: Mechanistic Insights on Confinement Effects in Small Molecule Activation
Contains fulltext : 326875.pdf (Publisher’s version ) (Open Access)
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Two-electron mixed-valence complexes small molecule activation and photocatalytic hydrogen production
Two-electron mixed-valence complexes of rhodium may be supported by diphosphazane ligands (RN(PY2)2). Whereas diphosphazane ligands with strongly [pi]-acidic phosphine groups (Y = F, OCH2CF3) react with RhI starting materials to afford binuclear Rh20,II complexes, Rh20,II(MeN(PY)2)3X2(L) or …
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Studies of alkali metal compounds in diesel fuel and small molecule activation chemistry
… related interest is the expanding field of small molecule activation chemistry, with CO2 being a prime example of an environmentally damaging small molecule produced by diesel engines. Despite the worldwide activity in both small molecule activation and alkali metal-based chemistry, no …
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Bioinorganic hydrocarbon oxidation : mechanistic and kinetic studies of the soluble methane monooxygenase from Methylococcus capsulates (bath)
Chapter 1. Principles of Small Molecule Activation by Metalloproteins as Exemplified by the Soluble Methane Monooxygenase -- Chapter 2. Small Molecule Binding to the Mixed-Valent Diiron Center of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) as Revealed by ENDOR …
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Templating Metal Clusters via Resorcinarene- and Cyclen- Based Ligand Platforms
… heterogeneous catalysts, play a critical role in small molecule activation by enabling multi-electron redox transformations through cooperative reactivity. One of the most compelling examples is biological nitrogen fixation, mediated by the nitrogenase enzyme, which offers a blueprint for …
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Coordination chemistry of unusual oxidation states of nickel and palladium relevant to homogeneous catalysis
… not limited to, cross-coupling catalysis, C-H activation, olefin polymerization, and cross-electrophile coupling. In addition, several metalloenzymes found in Nature that catalyze important small-molecule activation processes feature Ni at their active site. The commonly accepted mechanism of …
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Oxyanion reduction in a non-heme iron system
… metal center in the active site. Inspired by the small molecule activation performed by biological systems and the work of others in the area of bioinorganic chemistry creating biomimetic systems, our group designed a tripodal ligand platform featuring a secondary coordination sphere. The ligand …
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The reactivity and cation exchange of MOF-5
… for subsequent use in coordination chemistry and small-molecule activation. Rather than reproduce known metal species, this work harnesses the intrinsic properties of the MOF-5 lattice to isolate species that are difficult or impossible to achieve with solution-phase molecules or even other …
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Development of PAC-1 as a privileged agent for combination chemotherapy
… exploiting cancer-specific cellular alterations. Small-molecule activation of procaspase-3 represents a particularly promising opportunity, based upon its determinant role in the execution of apoptosis and its widespread over-expression across many diverse cancer types. PAC-1 is a small-molecule …
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