Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Small Heterodimer Partner (SHP)"”.
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Elucidating the role of small heterodimer partner (SHP) in metabolism, injury and systemic disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Uncovering a novel role for FXR-SHP axis in liver physiology, diseases and beyond
… the role of two nuclear receptors, FXR and SHP in maintaining liver function. Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP) are well-known regulators of glucose, fat and bile acid homeostasis. Here, I uncover novel roles for FXR-SHP axis not only in the liver but also in …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… receptors, farnesoid X receptor (FXR) and small heterodimer partner (SHP), have been identified as key regulators in bile acid signaling. FXR was revealed as the first in vivo bile acid biosensor and was shown to regulate cholesterol/bile acid homeostasis by suppressing the transcription of …
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Elucidating the Molecular Mechanisms Underlying the Hepatic Farnesoid X Receptor (FXR)-mediated Effects that Contribute to the Triglyceride-Lowering Ability of a Grape Seed Proceyanidin Extract
… farnesoid x receptor (FXR), thereby increasing small heterodimer partner (SHP) messenger ribonucleic acid (mRNA) expression, which then inhibits transcription of Sterol Regulatory Element Binding Protein 1c (SREBP-1c), a key transcription factor regulating lipogenic gene expression. The …
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Role of Src phosphorylation of FXR in bile acid regulation
… factor 19 (FGF19) and orphan nuclear receptor small heterodimer partner (SHP). In response to elevated hepatic bile acid levels FXR, acting directly as well as through FGF19 and SHP, inhibits the synthesis of bile acids, downregulates bile acid importers, upregulates bile acid exporters along …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
Small Heterodimer Partner (SHP, NR0B2), a member of the nuclear receptor superfamily, is an orphan receptor that lacks a DNA binding domain but contains a putative ligand binding domain. SHP forms non-functional heterodimers with DNA binding transcriptional factors and, thereby, functions as a …
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Gene selective regulation by hepatic Farnesoid x receptor (fxr) in health and disease
… to FXR-responsive DNA elements (FXRE) with a heterodimer partner, RXRα, in response to bile acids or other physiological stimuli. Interestingly, our group reported that FXR is aberrantly acetylated in fatty liver induced by a high fat diet, and acetylation of FXR impaired its ability to form a …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… pathway. MicroRNAs (miRs) are a class of small noncoding RNAs, usually 20-22 nucleotides long, first processed in the nucleus by the enzyme Drosha and then processed to its mature form in the cytoplasm by Dicer. MiRs usually function as negative post-transcriptional regulators by either …