Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Small Heterodimer Partner"”.
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
These combined studies should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 …
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Elucidating the role of small heterodimer partner (SHP) in metabolism, injury and systemic disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
Small Heterodimer Partner (SHP, NR0B2), a member of the nuclear receptor superfamily, is an orphan receptor that lacks a DNA binding domain but contains a putative ligand binding domain. SHP forms non-functional heterodimers with DNA binding transcriptional factors and, thereby, functions as a …
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Characterization of intestinal small heterodimer partner and farnesoid X receptor in bile acid and lipid metabolism
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Uncovering a novel role for FXR-SHP axis in liver physiology, diseases and beyond
… liver function. Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP) are well-known regulators of glucose, fat and bile acid homeostasis. Here, I uncover novel roles for FXR-SHP axis not only in the liver but also in extrahepatic organs, like heart. In Chapter 2, I discuss how hepatic …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… receptors, farnesoid X receptor (FXR) and small heterodimer partner (SHP), have been identified as key regulators in bile acid signaling. FXR was revealed as the first in vivo bile acid biosensor and was shown to regulate cholesterol/bile acid homeostasis by suppressing the transcription of …
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Elucidating the Molecular Mechanisms Underlying the Hepatic Farnesoid X Receptor (FXR)-mediated Effects that Contribute to the Triglyceride-Lowering Ability of a Grape Seed Proceyanidin Extract
… farnesoid x receptor (FXR), thereby increasing small heterodimer partner (SHP) messenger ribonucleic acid (mRNA) expression, which then inhibits transcription of Sterol Regulatory Element Binding Protein 1c (SREBP-1c), a key transcription factor regulating lipogenic gene expression. The …
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Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Uncovering the role of bile acid signaling in facilitating sex differences during hepatocarcinogenesis and liver metabolism
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Role of Src phosphorylation of FXR in bile acid regulation
… factor 19 (FGF19) and orphan nuclear receptor small heterodimer partner (SHP). In response to elevated hepatic bile acid levels FXR, acting directly as well as through FGF19 and SHP, inhibits the synthesis of bile acids, downregulates bile acid importers, upregulates bile acid exporters along …
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Gene selective regulation by hepatic Farnesoid x receptor (fxr) in health and disease
… to FXR-responsive DNA elements (FXRE) with a heterodimer partner, RXRα, in response to bile acids or other physiological stimuli. Interestingly, our group reported that FXR is aberrantly acetylated in fatty liver induced by a high fat diet, and acetylation of FXR impaired its ability to form a …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… pathway. MicroRNAs (miRs) are a class of small noncoding RNAs, usually 20-22 nucleotides long, first processed in the nucleus by the enzyme Drosha and then processed to its mature form in the cytoplasm by Dicer. MiRs usually function as negative post-transcriptional regulators by either …