Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Small G-protein"”.
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Nuclear accumulation of G-actin in cellular senescence: Reduced expressions of exportin 6 and Ran small G protein
… is a highly conserved, ubiquitous cytoskeletal protein, which contains two leucine-rich nuclear export signal (NES) sequences in the middle of the molecule. It has been known that actin is exclusively kept in the cytoplasm by exportin 1 (CRM1)-driven nuclear export. However, CRM1 has been …
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The role of ACK in regulating the Vav family proteins
… identify new binding partners of ACK. 14 novel proteins that interact with ACK were identified, one of which was a small G protein regulator Vav3, the least-studied member of Vav-family proteins. The first part of this project characterised the interactions between ACK and Vav-family proteins in …
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Investigating the Functional Interaction between RhoGDI Family Proteins and Activated Cdc42 associated-kinase (ACK)
… a non-receptor tyrosine kinase and an effector protein for Cdc42. ACK has been implicated in carcinogenesis events especially in promoting cell migration and invasion, indicating a need for a fuller understanding of the cellular roles of ACK both in normal and pathological conditions. A previous …
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Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions
… guanine-nucleotide exchange factors for the small G-protein Rho is necessary for proper actomyosin ring contraction and cytokinesis. Additionally we demonstrate that Polo-like-kinase-1 directly regulates the activity of the Rho-effector-kinase ROCK2, and thus Polo-like kinases modulate Rho …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… conserved, lysosome-mediated pathway of protein degradation, is a key participant in pathological cardiac remodeling. One common feature of cell growth and autophagy is membrane biogenesis and processing. The exocyst, an octomeric protein complex involved in vesicle trafficking, is …
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Interactions of the Striatal Gene Rhes with the Dopaminergic System in Rodents
Mice that are incapable of expressing the small G protein Rhes have been generated and have shown to have abnormalities in behaviors mediated by the striatum, a region in which Rhes is highly expressed. Moreover, conditions that result in dopamine supersensitivity and a breakdown in D1/D2 synergism …
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The P-Rex1 Regulator Norbin Suppressess Neutrophil-Dependent Antibacterial Immunity
… exchange factor (GEF) that activates the small G protein Rac, thus regulating a wide range of physiological and pathophysiological responses. Neutrophils are leukocytes of the innate immune system in which P-Rex1 regulates several Rac-dependent responses, especially those elicited by GPCR …
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Investigating the C-terminal region of RalA: regulation through membrane dynamics and protein-protein interactions
… there is a growing need to understand these proteins in terms of their structure and function to facilitate future pharmaceutical intervention in this critical oncogenic pathway. So far, biophysical characterisation of Ral proteins has typically been carried out with truncated constructs that …
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Small gtp-binding proteins in insulin secretion
… diabetes. GSIS involves interplay between small G-proteins and their regulatory factors. Herein, I tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide exchange factor [GEF] for the small G-protein Arf6, mediates the activation of Arf6, and that …
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Exploring the Importance of PREX Proteins in Glucose Homeostasis and Insulin Signalling
PREX protein family (PREX1 and PREX2) guanine-nucleotide exchange factors (GEFs) activate the small G protein Rac. They are important in many physiological and pathophysiological processes, including inflammation, neuronal plasticity, cancer progression and metastasis, with an exciting new role in …
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Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant
… and phospholipase D (PLD) via recruitment of the small G-protein ADP-Ribosylation Factor (ARF). This thesis focusses on protein:protein interactions and signalling mechanisms of the 5-HT2AR and H452Y-5-HT2AR receptor variant. Both ARF1 and PLD1 have previously been shown to bind to the …
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Biophysical and structural characterization of components from the nuclear pore complex and the ubiquitin pathway
… embedded in the NE and is composed of only -30 proteins that assemble with octagonal symmetry as biochemically defined subcomplexes to form the NPC. One such subcomplex is the Nspl / Nup62 complex, composed of three proteins and stabilized by coiled-coil interactions. Here we reconstitute a …
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Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
… catalyzes the post-translational modification of proteins by formation of intra- and intermolecular protein cross-links or by primary amine incorporation. TGase has various physiological functions, such as skin-barrier formation and blood clot stabilization, whereas increasing evidence indicates …