Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Small G proteins"”.
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Small gtp-binding proteins in insulin secretion
… diabetes. GSIS involves interplay between small G-proteins and their regulatory factors. Herein, I tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide exchange factor [GEF] for the small G-protein Arf6, mediates the activation of Arf6, and that …
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Developmental and Cellular Functions of Delta-Catenin
… compartments and modulates cadherin stability, small GTPase activities and gene transcription. In mammals, delta-catenin exhibits neural specific expression, with its knock-out in mice correspondingly producing cognitive defects and synaptic dysfunctions.</p> <p>My work instead employed the …
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
<p>Activation of Rho family small G proteins is thought to be a critical event in breast cancer development and metastatic progression. Rho protein activation is stimulated by a family of enzymes known as guanine nucleotide exchange factors (Rho GEFs). The neuroepithelioma transforming gene 1 …
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Novel interactions of the 5-HT₂ₐ and related receptors with intracellular signalling proteins
… interact with and signal through the trimeric G-proteins. The 5-hydroxytryptamine 2A receptor (5- HT₂ₐR) is a member ofthe group I family of rhodopsin-related GPCRs. The receptor is known to activate phospholipase C (PLC) via the heterotrimeric G proteins Gaq/n, but has been shown to also signal …
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Activation of lipid kinase VPS34 by Rab GTPases
… In the cell, VPS34 has to team up with other proteins in order to increase its enzymatic activity. It forms primarily two hetero-tetrameric complexes, complexes I and II, which act as key regulators of autophagy and endocytic trafficking, respectively. Complex I consists of VPS34, VPS15, …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
Lipids and proteins are two major components of cells, which are crucial for structural integrity and maintenance of cellular homeostasis by integrating various extracellular and intracellular cues. Lipids are involved in the regulation of cellular functions and can interact with proteins and …
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The role of ACK in regulating the Vav family proteins
… identify new binding partners of ACK. 14 novel proteins that interact with ACK were identified, one of which was a small G protein regulator Vav3, the least-studied member of Vav-family proteins. The first part of this project characterised the interactions between ACK and Vav-family proteins in …
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A New Approach To Identifying Effectors and Regulators of Small GTPases
… endomembrane system. It is widely accepted that small GTPases of the Ras superfamily are major regulators of membrane trafficking and signalling, ensuring specificity and efficiency through their spatiotemporal regulation.Identifying the proteins interacting with small GTPases is vital for …
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The Role of Sirtuin Inhibitors on the Proteomic Responses of the Mussels Mytilus galloprovincialis and Mytilus trossulus to Menadione Induced Oxidative Stress
… spectrometry, we were able to identify 32-41% of proteins, depending on the species.</p> <p>The two <em>Mytilus</em> congeners showed the greatest differences in changes of protein abundance for oxidative stress proteins (including NADP-dependent isocitrate dehydrogenase). Both congeners showed …
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Biophysical and computational insights into the stability of RhoB and its cancer-associated variants
RhoB is a small GTPase, part of the Rho family of the Ras superfamily of small G proteins, that act as cellular signalling switches. RhoB is involved in regulating the cytoskeleton, angiogenesis, cell death, endosome trafficking and DNA damage repair. Unlike other small GTPases such as K-Ras, RhoA …
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Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
… catalyzes the post-translational modification of proteins by formation of intra- and intermolecular protein cross-links or by primary amine incorporation. TGase has various physiological functions, such as skin-barrier formation and blood clot stabilization, whereas increasing evidence indicates …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… factor for the Rac family of cytoplasmic small G proteins, which has previously been found to be critical for T cells and immunity in mice and humans. The second mutation was a synonymous exonic nucleotide substitution in Senp2, encoding a specific protease for cleaving the ubiquitin-like …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… factor for the Rac family of cytoplasmic small G proteins, which has previously been found to be critical for T cells and immunity in mice and humans. The second mutation was a synonymous exonic nucleotide substitution in Senp2, encoding a specific protease for cleaving the ubiquitin-like …