Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Small Cell Lung Carcinoma"”.
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC …
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Surveillance Imaging Following Curative-Intent Surgery for Non-Small Cell Lung Carcinoma: A Systematic Review
Following curative surgery for non-small cell lung carcinoma (NSCLC), patients remain at risk for recurrence of lung cancer or for development of second primary lung cancer (SPLC). While periodic surveillance may detect early stage recurrence or SPLC, the effectiveness of surveillance has not been …
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Tumour Associated Neutrophils as a Potential Biomarker for Anti-PD-1 Immunotherapy in Non-Small Cell Lung Carcinoma: An Automated Approach
… and clinical biomarkers for the treatment of lung adenocarcinoma (LUAD), objective response rates are still low at around 20%. Current biomarkers are limited in their ability to stratify patients for predicting response, highlighting the need for novel biomarkers to better guide therapeutic …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
<p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Outcomes are poor for patients with recurrent, advanced or metastatic NSCLC. Polo-like kinase 1 (PLK1), involved in the regulation of mitotic processes and the response to DNA damage, is overexpressed in …
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The role of c-FLIP in regulating resistance to ionizing radiation
… strategies to improve the efficiency of cell death induction by ionizing radiation (IR) are required to improve therapeutic outcomes. FLIP, anendogenous caspase-8 inhibitor is a critical regulator of cell death that is frequently overexpressed in various cancers. FLIP overexpression in …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
… factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was determined that NSCLC cell lines (A549, …
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Identification of signalling pathways regulating TBX2 gene expression and its target genes
… suggest that they function in controlling cell cycle progression and also in the genesis of cancer. Importantly, the T-box factors Tbx2 and Tbx3 are overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver and bladder cancers and can suppress …
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Design, Synthesis and Biological Evaluation of Inhibitors of Polysialyltransferases PST and STX. Design, synthesis and biological evaluation of a range of N-modified mannosamines, sialic acids and analogues from in silico screening as inhibitors of PolySia-NCAM biosynthesis with anti-migration activity.
… re-expressed in a number of tumours, including small cell lung carcinoma and neuroblastoma and is strongly associated with aggressive, invasive and metastatic tumours in the clinic. SiRNA knockdown of the polysialyltransferases (polySTs), the enzymes responsible for polysialylation of neural …
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Epigenetic Therapy of Lung Cancers: Anti-tumoral effect of valproate on small cell lung cancer
Lung cancer is the leading cause of cancer-related death worldwide. Among lung carcinomas, the outcome of small cell lung carcinoma (SCLC) patients is the poorest of any histological subtype with five-year survival rate of less than 20 and 5 % for limited and extensive stage respectively. Based on …
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Expression of Leukemia/Lymphoma Related Factor (LRF) in Human Breast Carcinoma
… oncogenic role is known only in lymphoma, non-small cell lung carcinoma, and malignant gliomas. The functional expression of LRF in human breast carcinoma has not been confirmed. The aim of this study was to investigate the expression of LRF and propose a mechanism for its function in human …
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T Cell Immunosurveillance in Pancreatic Ductal Adenocarcinoma
ABSTRACT T CELL IMMUNOSURVEILLANCE IN PANCREATIC DUCTAL ADENOCARCINOMA Rebecca A. Evans Robert H. Vonderheide The prevailing theory of cancer immune surveillance, as understood from carcinogen-driven mouse models of highly mutated tumors, states that T cell-mediated immune pressure drives a …
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Optimization of BRAF V600 Assay as A 2-Step Real-time PCR Protocol
… abnormally active, which disrupts regulation of cell growth and division. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even prostate cancer. …
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Regulatory roles of endothelial cells in cancer
… the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view of tumor vessels from perfusing tubes to delivery platforms lined with potent paracrine regulatory …
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Novel Roles for A-Type Lamins in Maintaining Genomic Stability
… are associated with different cancers such as small cell lung carcinoma and gastrointestinal neoplasms. Despite the prevalent link between A-type lamins and disease, the molecular mechanisms behind lamins-associated pathogenesis are poorly understood. Elucidation of these mechanisms would …
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Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer
… agent for breast, ovarian, pancreatic and non-small cell lung carcinoma. Till date, PTX has been used as the first line of treatment for metastatic breast cancer. However, being biopharmaceutical classification system (BCS) class IV agent PTX suffers low solubility, poor permeability and …
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Elucidating the role of the EGFR-family members in cell motility through the use of novel engineered bivalent ligands
Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer and is the leading cause of cancer related mortality worldwide. The past decade has seen exciting advances in the development of targeted therapies for the treatment of NSCLC. However, the efficacy of such therapies in …
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Development of Models for the Action of Novel Anti-apoptotic Proteins using Gene Regulation, Pathway Analysis and Protein Structure Prediction
… genes. Some of these cancers, such as non-small cell lung cancer (NSCLC), can only be detected at an advanced stage and therefore have a low survival rate. <br/>This project was designed in collaboration with Morvus Technology Ltd with the goal of using modern bioinformatics tools to …
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An immunohistopathological and functional investigation of β3 integrin antagonism as a therapeutic strategy in cancer. Characterisation, development, and utilisation of preclinical cancer models to investigate novel ¿3 integrin anatgonists.
Tumour cell dissemination is a major issue with the treatment of cancer, thus new therapeutic strategies which can control this process are needed. Antagonism of integrins highly expressed in tumours is one potential strategy. The integrins are transmembrane glycoprotein adhesive receptors. Two of …
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Utilization of fish for constitutional and acquired chromosomal abnormalities for diagnostic and prognostic purposes
… to pathological and clinical characteristics of small cell lung carcinoma (SCLC). The correlation between del(5q) and spindle cell morphology was found to be significant (p<0.025), but of unknown relevance. In the second study, FISH was used in conjunction with microarray analysis to define the …
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Genome-Wide Analysis of Transcription Factors Ascl1 and Ptf1a in Development and Cancer
Cell fate specification in the developing embryo relies on combinations of transcription factors to regulate tissue specific gene programs. Many of the same transcription factors can be found in multiple tissue types and are crucial for their development, and at other times these same factors can …
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