Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Smads"”.
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Identification and Characterization of the TGFβ/Hippo Crosstalk through Mathematical Modeling
… Taz/Yap interact with the TGFβ regulated Smads and when Hippo is activated, the cytoplasmically localized Taz/Yap reduces or prevents Smad nuclear accumulation thereby dampening TGFβ induced transcriptional activity. In the nucleus, Taz/Yap can transcriptionally cooperate with Smads to …
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Signal transduction of transforming growth factor-Beta in cytotoxic T cells
… von Rezeptor-assoziierten Smad-Proteinen (R-Smads). R-Smads werden vom Typ I Rezeptor aktiviert, der seinerseits vom hochaffinen Typ II Rezeptor phosphoryliert wird, sobald der Ligand bindet. Die phosphorylierten RSmads assoziieren darauf mit Co-Smads. Heterooligomere von R-Smads und Co-Smads …
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The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
… and activate the R-SMAD transcription factors. R-SMADs translocate to the nucleus and regulate the transcription of hundreds of genes. The cellular responses to TGFß/BMP signals are tightly controlled and highly regulated. TGFß/BMP receptors and R-SMADs, as the intracellular mediators of TGFß/BMP …
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Immunological Crosstalk between Human Transforming Growth Factor-β1 and the Malaria Vector Anopheles stephensi
… human TGF-β can activate Drosophila melanogaster Smads, the proteins responsible for TGF-β signal transduction. We have determined that following a bloodmeal, active human TGF-β1 (hTGF-β1) persists in the midgut of A. stephensi for up to 48 hours. My data demonstrate that the midgut epithelium …
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Body Size Regulation via BMP Signaling in <i>Caenorhabditis elegans</i>
… (EMSA), I showed functional conservation of Smads in C. elegans via strong and specific SMA-4 binding to GTCT (Smad Binding Element) sites. I have discovered a stage specific requirement of Smads for expression of cuticle collagen genes. Based on our work we emphasize that cuticle collagens …
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Effects of Docosahexaenoic Acid on TGF-ß and SMAD Proteins in COLO205 and WiDr Cells
… as well as related transcription factors called SMADs, are among the proteins known to be modified by docosahexaenoic acid (DHA) treatment in T-cells. Unpublished data has indicated that these proteins may be modified by DHA in colon cancer cells. In the current project, a thorough investigation …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
… the MAPK pathways we tested, the BMP–specific Smads 1 and 5 are activated in response to TGF–β in these cells, and this activation is dependent on ALK5 kinase activity. Collectively, these data indicate that TGF–β induces growth inhibition in B lymphocytes through a novel signaling pathway, and …
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TGFβ signalling in microglia and the impact of microglia-specific Smad4 deletion
… the interaction and subcellular distribution of Smads, and the cross-talk between different TGFβ superfamily receptors. It also delineates the canonical and non-canonical TGFβ signalling in microglia and the effect of lipopolysaccharide (LPS)-induced reactive state on microglia TGFβ signalling. …
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TGF-beta signaling at the cellular junctions
… found that TGF-beta ligands, receptors and R-Smads show a polarized distribution both in the epithelial cells and at the synapses. My results indicate that the cellular junctions define a signaling domain within the plasma membrane, to which TGF-beta signaling machinery is targeted. In the …
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L’implication de la signalisation des Bmps dans le maintien de l’homéostasie de la muqueuse intestinale et colique et dans les pathologies digestives.
… et l’organogenèse du tube digestif. Les BR-Smads, Smad1, Smad5 et Smad8, sont les effecteurs intracellulaires de cette cascade de signalisation et ils assurent la biodiversité des réponses biologiques associées aux Bmps. Plusieurs études ont démontrées des rôles importants pour le TGF-β dans …
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Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… a different phosphorylation pattern of R-Smads. Together with an inferior role of TßRI, Smad3 is proposed to serve as a substrate for cellular kinases other than TßRI. Based on the presented involvement of components of both, the MAPK/Erk and the TAK1/MKK6 cascade, signal mediators of …
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The Effect of Radiation and Repeated Sub-culturing on TGF-β1 Signaling in FRTL-5 Cells
… respectively. The levels and activity of Smads 2, 3, 4 and 7, downstream effectors in the TGF-β1 signaling pathway were also measured via western blotting. Lastly, we examined whether TGF-β1 was correctly regulating the expression of its response genes; cyclin A and plasminogen activator …
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Isolierung, Charakterisierung und Funktionsanalyse von TGF-Beta-Signaltransduktionskomponenten des Fuchsbandwurms Echinococcus multilocularis
… EmSmadC eine MH1-Domäne, die sonst unter allen R-Smads hoch konserviert ist. Zudem sind einige bislang noch nie beschriebene, strukturelle Besonderheiten der Echinococcus TGFβ/BMP-Rezeptoren zu verzeichnen. Auch die Regulation dieser Faktoren und die Kreuz-Interaktion mit weiteren intrazellulären …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
Gastrulation is the process by which the three germ layers are generated during vertebrate development. Nodal ligands, which form a subgroup of the Transforming Growth Factor β (TGFβ) superfamily, regulate the expression several transcription factors implicated in gastrulation. Among these are the …
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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… This dissertation highlights the role of activin/SMADs signaling in adipose tissue development, function, and maintenance.</p> <p>SMAD2/3 proteins are downstream mediators of transforming growth factor-β (TGFβ) family signaling, including activins, which regulate critical preadipocyte and mature …
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Effects of carbohydrates on iron metabolism in intestinal and liver cells
… or greater changes in HepG2 gene expression of SMADs 2 and 3, STAT3 and NF-κb -- signalling proteins implicated in development of inflammatory liver disease; increased HepG2 mRNA expression of cell cycle related genes, Cyclin D1 and Cyclin D2, and the proto-oncogene Skp2; decreased mRNA …