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Showing 1 to 20 of 21 for “"Smad7"”.
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Functional analysis of SMAD7 in mammallian heart development
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Transgenic use of SMAD7 to suppress TGFß signaling during mouse development
… However, it remains unclear what role Smad7, a negative regulator of TGFβ superfamily signaling, plays during development and moreover what the spatiotemporal effects are of combined suppression of TGFβ superfamily signaling during NCC formation and colonization of the developing …
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Expressionsstudien und Mutationsanalyse des TGF-[beta]-Antagonisten Smad7 in menschlichen hepatozellulären Karzinomen
… and form a transcriptionally active complex. Smad7 has been identified, a player that antagonizes rather than transduces TGF-Beta-family signals by acting downstream of TGF-Beta receptors. TGF-Beta rapidly induces the expression of Smad7 mRNA, suggesting participation in a negative feedback …
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… pathway in this process by overexpression of Smad7, an intracellular antagonist of TGF-beta signaling. Moreover, a new TGF-beta response gene was identified, which participates in the control of profibrogenic transdifferentiation to myofibroblast-like cells. Ligation of the common bile duct …
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Ο ρόλος του SMAD σηματοδοτικού μονοπατιού στις σπειραματονεφρίτιδες του ανθρώπου
… της έκφρασης των παραγόντων pSmad2/3, p300, Sp1, Smad7 και Ski (μορίων που συμμετέχουν στο Smad σηματοδοτικό μονοπάτι) σε νεφρικές βιοψίες ασθενών με ΣΝ και η ανίχνευση της δράσης τους όσον αφορά την παθογένεση και την εξέλιξη της νεφρικής βλάβης. Χρησιμοποιήθηκαν 157 βιοψίες ασθενών με ΣΝ και 15 …
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Morphological characterization of liver fibrogenesis in animal models with genetically modulated TGF-beta signal transduction
… signaling (Massague 1998 and Piek et al.,1999). Smad7 belongs to inhibitory Smad propteins.(I-Smad) exerting their inhibitory effect on TGF-beta by binding to the T beta RI to hinder posphorylation of Smad2 (receptor Smad, R-Smad) and subsequent signaltransduction pathway to nucleus. Because the …
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TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte
… immunohistochemistry. RT-PCR for Smad2, 3, 4 and Smad7 was conducted with total RNA and Northern blot analysis for Smad3 and 7 with mRNA. Whole liver lysates were prepared to detect Smad4 by Western blotting. Results: Smad7 expression was continuously increasing with duration of cholestasis. Smad2 …
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Unterschiede in der TGF-[beta]-vermittelten Signaltransduktion in aktivierten hepatischen Sternzellen unterhalb der Smad2-Phosphorylierung
… treatment lead to upregulation of PAI-1, Smad7 and (CAGA)9-MLP-Luc subsequent to Smad2 phosphorylation. Two further TGF-beta responsive genes, TIMP-1 and type I collagen were not affected. In contrast to primary cultured HSC, which were inhibited in their growth, TGF-beta1 did not …
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The low-level light therapy affects human dermal fibroblast via TGF-β/smad signaling pathway: in vitro study
… of collagen type I, TGF-ß1, smad3 and smad7 after incubation with exogenous TGF-ß1 13 IV. DISCUSSION 17 V. CONCLUSION 22 REFERENCES 23 국문요약 28
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Acute pancreatitis, from local defense to remote organ injury
… with an increase in the level of inhibitory Smad7. The level of Smad7 was back to the control level after 24 h when there was an increase in the nuclear translocation of phosphorylated Smad2. Our findings suggest that TGF-β signaling pathway can be activated in the early phase of ALI due to …
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An Evaluation of Transforming Growth Factor-β Signalling in Adult Glioblastoma
… The bioinformatics data highlighted TGFβ2, SMAD7 and SARA as potential targets for GBM therapy. Using recombinant DCN in vitro to then modulate TGFβ signalling did not have a demonstrable effect on GBM cell proliferation. Interestingly, preliminary data suggest that DCN abrogates the …
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AN INVESTIGATION OF POTENTIAL MECHANISMS UNDERLYING CHEMOSUPPRESSIVE EFFECTS OF DIETARY FLAXSEED IN THE LAYING HEN MODEL OF OVARIAN CANCER
… ovarian cancer. However, expression of SMAD6 and SMAD7 was upregulated in tumors from hens on the flaxseed diet but not control diet, with SMAD7 protein being expressed in both epithelial tumor cells and intratumoral stromal cells. Additionally, immunohistochemical staining for pSMAD2/3 was …
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Der Transkriptionsfaktor FKHR interagiert mit STAT-Faktoren und verstärkt die IL-6-Signaltransduktion
… as well but could not be observed for STAT5 or Smad7. Growth factors activate via PI3 kinase the PkB which phosphorylates FKHR at serin/threonin phosphorylation sides. This forces FKHR to leave the nucleus. A reduction of acute phase proteins synthesis and secretion results from stimulating …
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Regulation of amnion induction during the human formative pluripotency transition
… in embryo. TGF-β inhibition downregulates SMAD7, facilitating increased BMP signalling which drives AME induction—a mechanism distinct from AME differentiation from primed hPSCs. Notably, the core pluripotency factor NANOG is suppressed by TGF-β/Nodal inhibition in capacitating cells but …
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Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… manner. Negative regulation is provided by Smad7 which was found to act as a potent inhibitor of Smad signaling not only in TGF-ß- but also in NGF-mediated cascades. The potential of NGF to activate the Smad pathway independent of TGF-ß might be of special importance in regulating expression …
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Genetic Analyses of Tumor Progression in Colorectal Cancer
… Second, loss of 18q and gain of 8q harboring SMAD7 and PTP4A3 appear to rise during progression defined as early (Dukes A and B) to late (Dukes C and D) tumor stage. Third, distant metastatic potential may be associated to loss of 8p and increased expression of miR-373. Fourth, putative …
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Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
… auf TGF-β Signale selbst ausüben können wie Smad7, Igf2r und Fstl3. Durch die Regulation von Genen, die an der Übertragung von Notch- und Wnt-Signalen beteiligt sind, konnte eine Interaktion von TGF-β Signalwegen mit den an vielfältigen Entwicklungsprozessen beteiligten Notch- und …
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Untersuchungen zur Regulation der humanen Xylosyltransferase-I bei Fibrosen
… regulation by miRNA-21, the inhibitory SMAD7 was identified as secondary mediator. To address the missing association of increased XT serum activity with increased cellular XYLT1 mRNA expression und XT-I activity in SSc, this study characterized the differences in cellular XT-I activity …
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Smad Proteins and theTgf-Beta Signaling Pathway During In Vitro Progression of Hpv16-Immortalized Human Keratinocytes' and 'Microarray Gene Expression Profiling of Exfoliated Cervical Cells'
… or increase in protein expression of inhibitory Smad7 that paralleled the increasing loss of sensitivity to the growth inhibitory response to TGF-β observed in our in vitro model of HPV16-mediated transformation. We did observe delayed TGF-β signaling, as assessed by Smad3 nuclear accumulation …
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