Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Smad signaling"”.
-
TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… pathway in this process by overexpression of Smad7, an intracellular antagonist of TGF-beta signaling. Moreover, a new TGF-beta response gene was identified, which participates in the control of profibrogenic transdifferentiation to myofibroblast-like cells. Ligation of the common bile duct …
-
The low-level light therapy affects human dermal fibroblast via TGF-β/smad signaling pathway: in vitro study
… of LLLT on the expression of mRNA of TGF-ß/smad signaling molecules 9 C. The effect of LLLT on the protein expression of TGF-ß/smad signaling molecules 12 D. Protein expression of collagen type I, TGF-ß1, smad3 and smad7 after incubation with exogenous TGF-ß1 13 IV. …
-
Endometrial Decidualization by TGF-β and PPAR-γ
… receptors and transducer proteins in the TGF-β signaling. And we examined the cultured endometrial stromal cell treated with TGF-β and/or PPAR-γ agonist using western blotting, confocal microscopy, and cell counting. RESULTS: The results revealed a significant increase in the level of both TGF-β …
-
Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… Upon activation, the receptors phosphorylate Smad proteins which serve as downstream mediators that enter the nucleus and finally trigger transcriptional responses of specific genes. During the past years, it became evident that signaling cascades do not proceed in a linear fashion but rather …
-
Mechanisms underlying rapid activity-dependent structural plasticity at Drosophila neuromuscular junctions
… rapid bouton budding requires retrograde BMP signaling and local alteration in the presynaptic actin cytoskeleton. BMP acts during development to provide competence for rapid synaptic growth by regulating the levels of the Rho GEF trio, a transcriptional output of BMP-Smad signaling. In a …
-
Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… caspase-3 cleavage. In contrast, BMP9-induced Smad1/5 and TGF-β–induced Smad2 phosphorylation remained unaltered, indicating that PMCA4’s anti-apoptotic role is independent of canonical Smad signaling. A luciferase reporter construct harboring the PMCA4 3′UTR was engineered to assess …
-
Cellular and Organismal Ramifications of de novo Purine Synthesis Dysregulation
… genetic information carriers, energy currency, signaling molecules, and cofactors for multiple processes. They are formed through <em>de novo</em> and salvage pathways found in cells across the phylogenetic tree. The substrates of enzymes within <em>de novo</em> purine synthesis are known to …
-
The activin a pathway in fetal testis development and dysgenesis in the mouse
… differentiation, and function via the SMAD signaling pathway. Inhibin βA (Inhba), the gene encoding activin A, is expressed within the interstitial compartment of murine and human fetal testes; however, the role of Inhba/activin A during testis morphogenesis is unknown. To investigate …
-
Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
… function of TG2 primarily through the canonical Smad signaling pathway. Increased TG2 expression level correlates with a mesenchymal phenotype of OC cells, suggesting that TGF-β1 induced TG2 promotes epithelial-to-mesenchymal transition (EMT). TG2 induces EMT by negatively regulating E-cadherin …
-
The Effect of Radiation and Repeated Sub-culturing on TGF-β1 Signaling in FRTL-5 Cells
… We hypothesized that alteration in the TGF-β1 signaling pathway contributed to the changes observed in the cellular properties of FRTL-5 cells. Our objective was to examine some of the players in the TGF-β1 signaling pathway to determine whether radiation and/or repeated subculturing promoted …
-
PROGRAMMED DEATH LIGAND 1 (PD-L1) IMMUNE CHECKPOINT-MEDIATED STIMULATION OF MALIGNANT PHENOTYPES IN TUMOUR CELLS
… checkpoint have focused on elucidating the signaling mechanisms leading to inactivation of immune effectors. We, along with others, have shown that signaling by the PD-1/PD-L1 immune checkpoint may be bidirectional. Hence, we hypothesized that PD-1/PD-L1 signaling promotes malignant …
-
Stem Cell-Based Immune Modulation and Regeneration
… with GO by activating a specific TGF-β/SMAD signaling pathway that enhances some pro-regenerative AEC properties such as cell migration and adhesion but simultaneously diminishes their ability to inhibit immune cell activation (PBMC), thus confirming that when AEC shift toward the …
-
Hedgehog signaling: a potential therapeutic target for non-small cell lung cancer
… protein levels causing activation of hedgehog signaling. These results were also reproduced in another NSCLC cell line (H2030), and these results were further associated with the induction of EMT phenotype. Induction of EMT was found to be consistent with aggressive characteristics such as …
-
Regulation of Hematopoietic Stem Cells
… summary, our results demonstrate that increased Smad4 expression, a key component in the transforming growth factor-β (TGF-β) signaling pathway, sensitizes human CB HSPCs to TGF-β. This leads to growth arrest and apoptosis in vitro and reduced HSPC reconstitution capacity in vivo with no effect …