Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Smad nuclear accumulation"”.
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The Effects of Atypical Protein Kinase C on TGFβ Signalling
… of the downstream transcription factor Smad2 through altered receptor membrane trafficking. Furthermore, I showed that aPKC activity and expression alters the phosphorylation and degradation of Par6, which in turn affects TGFβ induced EMT and migration. Finally, I examined global gene …
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Identification and Characterization of the TGFβ/Hippo Crosstalk through Mathematical Modeling
… Taz/Yap interact with the TGFβ regulated Smads and when Hippo is activated, the cytoplasmically localized Taz/Yap reduces or prevents Smad nuclear accumulation thereby dampening TGFβ induced transcriptional activity. In the nucleus, Taz/Yap can transcriptionally cooperate with Smads to …