Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Smad Signalling"”.
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Decoding the structure WWP2 in the TGFβ signalling pathway
… motifs found in the sequences of the Smad signalling proteins that propagate or inhibit the TGFβ pathway, and in so doing, allows WWP2 to regulate its Smad targets. WWP2 has three isoforms that are known to participate in regulation of TGFβ signalling, but, even amongst isoforms of the …
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… upregulates the neurotrophic factor BMP2 and BMP-Smad dependent transcription signalling in SH-SY5Y cells, the activation of which has been previously demonstrated to be neuroprotective in PD models. Finally, we determined that this activation of BMP-Smad signalling was necessary for the …
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The role of mechanotransduction in signalling and pluripotent stem cell fate
… mechanisms of interplay between soluble factor signalling and mechanical cues remain unclear. Further understanding of how mechanical factors of the extracellular matrix (ECM) affect pluripotency and cell fate will not only improve the differentiation of pluripotent stem cells in vitro, but also …
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The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
… but BMP9 is known to inhibit pro-angiogenic VEGF signalling. A microarray study conducted by the Morrell group in pulmonary artery endothelial cells after treatment with BMP9 revealed Semaphorin 3G (SEMA3G) as a potential BMP9-regulated gene. Class 3 semaphorins have been implicated in …
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Elucidating the regulatory mechanisms of pterygium
… with transforming growth factor β on cell signalling and function of pterygial derived fibroblasts. Methods: Pure fibroblast cultures were established from cell outgrowths of pterygial tissue. Immunochemistry techniques were used to identify cell phenotype, tissue features and cell …
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Characterisation of the molecular mechanisms of dopaminergic axonal growth and their impairment in Parkinson's disease
… growth factor effects by regulating the BMP-Smad signalling pathway. Therefore, for GDF5 to be a suitable candidate therapy for PD, it is important that the cellular response to GDF5 is unaffected by the disease process. In Chapter 2, we demonstrate that GDF5 signalling is normal in cellular …
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The Role of Bone Morphogenetic Protein Signalling in Adult Lung Health and Disease
Bone morphogenetic protein (BMP) signalling is essential for correct lung morphogenesis. The pathway controls branching morphogenesis in the nascent lung and is also involved in the establishment of correct epithelial cell distribution throughout the airways. In the adult lung, BMP signalling is …
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Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV)
… undertaken in this thesis were to delineate the signalling pathways used by Mstn and MSV in order to understand how their opposing roles in myoblasts regulate myogenesis. Initially, microarray analysis was used to investigate the transcriptional responses of ovine myoblasts following exposure to …
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The Effects of Atypical Protein Kinase C on TGFβ Signalling
The transforming growth factor beta (TGFβ) signalling pathway is an essential regulator of many cellular processes including epithelial growth control, epithelial to mesenchymal transition (EMT), apoptosis, and the establishment of developmental fate. Alterations in TGFβ signalling patterns are …