Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 89 for “"Smad"”.
-
Ο ρόλος του SMAD σηματοδοτικού μονοπατιού στις σπειραματονεφρίτιδες του ανθρώπου
… στη διαδικασία αυτή φαίνεται να διαδραματίζει το Smad σηματοδοτικό μονοπάτι που διαμεσολαβεί τα σήματα του TGF-β στα νεφρικά κύτταρα. Ο ρόλος του TGF-β στη νεφρική βλάβη είναι πλέον καλά τεκμηριωμένος. Αντίθετα ελάχιστα είναι γνωστά για την έκφραση και τη λειτουργία του Smad σηματοδοτικού …
-
Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… Upon activation, the receptors phosphorylate Smad proteins which serve as downstream mediators that enter the nucleus and finally trigger transcriptional responses of specific genes. During the past years, it became evident that signaling cascades do not proceed in a linear fashion but rather …
-
Effects of Docosahexaenoic Acid on TGF-ß and SMAD Proteins in COLO205 and WiDr Cells
… as well as related transcription factors called SMADs, are among the proteins known to be modified by docosahexaenoic acid (DHA) treatment in T-cells. Unpublished data has indicated that these proteins may be modified by DHA in colon cancer cells. In the current project, a thorough investigation …
-
The low-level light therapy affects human dermal fibroblast via TGF-β/smad signaling pathway: in vitro study
… of LLLT on the expression of mRNA of TGF-ß/smad signaling molecules 9 C. The effect of LLLT on the protein expression of TGF-ß/smad signaling molecules 12 D. Protein expression of collagen type I, TGF-ß1, smad3 and smad7 after incubation with exogenous TGF-ß1 13 IV. …
-
Smad Proteins and theTgf-Beta Signaling Pathway During In Vitro Progression of Hpv16-Immortalized Human Keratinocytes' and 'Microarray Gene Expression Profiling of Exfoliated Cervical Cells'
… in HKc/DR, we have previously shown using a Smad-driven luciferase reporter construct that TGF-β signaling is only reduced about 50% in HKc/DR as compared to HKc/HPV16. In the first section of the present thesis we studied whether alterations in the expression of the Smad components of the …
-
Identification of Regulatory DNA Region and Transcription Factors Important for TIM-3 Transcription
… TIM-3 발현 증가에서도 중요하게 작용함을 보였다. 또한 TGF-β 신호전달에 중요한 smad 2와 smad 4과발현 시스템을 이용하여 TGF-β에 의한 TIM-3 발현증가에 smad 2와 smad 4가 관여함을 제시하였다. 본 연구의 결과는 TIM-3 전사조절에 중요한 upatream DNA region을 밝힘으로써 TIM-3 발현 조절 기작을 이해하는데 중요한 초석이 된다.
-
Ueber die Funktion von Zinkfinger Proteinen bei der Induktion des Mesoderms in Xenopus laevis
… Familie reguliert. In der Zielzelle ver mitteln Smad Proteine die Signalweitergabe von der Zellmembran in den Zellkern. Hier kooperieren di e Smad-Proteine mit gewebsspezifischen Transkriptionsfaktoren, um Zielgene zu regulieren. In der Ta ufliege Drosophila melanogaster kooperiert das homologe …
-
Endometrial Decidualization by TGF-β and PPAR-γ
… that obtained from stromal cells. In addition, pSmad2/3 translocation from the cytoplasm to the nucleus was greatly enhanced in the secretory endometrium. Prolactin was used for endometrial decidualization marker. PPAR-γ is a member of streroid receptor superfamily of nuclear receptor. PPAR-γ is …
-
Isolierung, Charakterisierung und Funktionsanalyse von TGF-Beta-Signaltransduktionskomponenten des Fuchsbandwurms Echinococcus multilocularis
… II) und intrazellulären Signaltransduktoren der Smad-Familie besteht. Außer an Entwicklungsvorgängen tierischer Organismen könnte diesem System eine wichtige Rolle bei der Wirt-Helminth-Kommunikation während Infektionsprozessen zukommen, wie in vorherigen Studien am Nematoden Brugia malayi und am …
-
Characterisation of the molecular mechanisms of dopaminergic axonal growth and their impairment in Parkinson's disease
… growth factor effects by regulating the BMP-Smad signalling pathway. Therefore, for GDF5 to be a suitable candidate therapy for PD, it is important that the cellular response to GDF5 is unaffected by the disease process. In Chapter 2, we demonstrate that GDF5 signalling is normal in cellular …
-
Involvement of TGF-beta in skin photoaging
… of ROS vary with time. We showed that both Smad and non-Smad pathways, e.g. MAPK and PKC pathways, are required for TE mRNA up-regulation by TGF-[beta].
-
Body Size Regulation via BMP Signaling in <i>Caenorhabditis elegans</i>
… sequencing (ChIP-Seq). Furthermore, I have shown Smad binding to v conserved Smad Binding Elements (SBE) in a common promoter region for col-141 and col-142 and demonstrated that SBE in this region are required for gene expression. Utilizing electrophoretic mobility shift assays (EMSA), I showed …
-
Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
… and prolactin. This effect was mediated by Smad and ERK activation. Addition of rosiglitazone, a PPAR gamma agonist, prevented TGF-β1 effect on endometrial cell proliferation. Furthermore, rosiglitazone inhibited TGF-β1 induced activation of ERK, consequently reducing PGE2 and prolactin …
-
Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
… pathways. We wished to establish whether Smad proteins (involved in the downstream signalling cascade from BMPR) might play a role in human pulmonary and systemic arterial fibroblast proliferation to acute hypoxia. Following approval from the local Ethics Committee, PAFB were harvested …
-
Klonierung und Charakterisierung von Rezeptorkinasen der EGF- und TGF-Beta-Familie des kleinen Fuchsbandwurmes Echinococcus multilocularis
… intrazellulärer Signaltransduktionsfaktor der Smad- Familie aus dem Fuchsbandwurm Echinococcus multilocularis charakterisiert. Mittels degenerativer PCR und 3´/ 5´-RACE Methoden konnten drei E. multilocularis cDNAs identifiziert und vollständig charakterisiert werden, welche für (i) eine …
-
Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
… compounds inhibit TGFβR-II and TGFβ1-induced SMAD-dependent by reducing reporter activity, reduce the phosphorylation of SMAD3 proteins, and decrease the expression of pai-1 transcript. These green tea catechin compounds also decreased the BMP4-induced phosphorylation of p38 mitogen-activated …
-
Determining Mechanisms by which Pathological Extracellular Matrix induces Ocular Hypertensive Phenotypes in Human Trabecular Meshwork Cells
… independent of time. (2) GIM triggered non-Smad/TGFβ2 signaling in hTM cells, correlated with overexpression of key ECM structural/matricellular/crosslinking/turnover genes/enzymes; whereas GIM+TGFβ2 activated Smad and non-Smad/TGFβ2 signaling, associated with increased cell contractility …
-
Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
… a scratch assay. Immunoblot analyses of cofilin, Smad protein (Smad) 2/3, p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and extracellular signal related kinase expression were conducted to elucidate the cell signaling networks that contribute to the anti-fibrotic effect of …
-
The role of bone morphogenetic protein signalling in the control of skin repair after wounding. Cellular and molecular mechanisms of cutaneous wound healing mediated by bone morphogenetic proteins and their antagonist Noggin.
… To study this, transgenic mice overexpressing Smad1 (K14-caSmad1) or the BMP antagonist Noggin (K14-Noggin) were utilised, together with human and mouse ex vivo wound healing models and in vitro keratinocyte culture. In wild-type mice, transcripts for Bmpr-1A, Bmpr-II, Bmp ligands and Smad …
Page 1 of 5