Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Sld3"”.
-
Regulation of DNA replication by PP2A family phosphatases
… of the limiting initiation proteins, Sld2 and Sld3, is sufficient for CDK’s role in replisome activation in Saccharomyces cerevisiae. This modification permits a cascade of protein recruitment to origins that completes replisome assembly, however, Sld2 and Sld3 do not travel with the replisome …
-
The Role of the Protein MTBP in DNA Replication
… yeast, the proteins Sld2 and Sld3 are CDK substrates that interact with Dpb11, and are required for the assembly of the CMG complex. Sld7 has been reported to associate with Sld3 throughout the cell cycle and regulate the function of Sld3 at replication …
-
Treslin and its role in the assembly of the replicative DNA helicase
… suggested the importance of protein called Sld3/Treslin for CMG assembly. The aim of the project was to understand in detail how human Treslin participates in the assembly of the CMG helicase. The interactions of Treslin with Cdc45, Mcm2–7, and DNA were characterised by a series of …
-
S-phase checkpoint activity and function throughout the cell cycle
… for Rad53 to phosphorylate the initiation factor Sld3, the key residues of Cdc45 necessary for Rad53 interaction were identified. A Cdc45 allele was produced by mutating the identified residues. This allele of Cdc45 is a separation-of-function mutant which prevents Sld3 phosphorylation upon DNA …
-
Identification of TICRR, a novel checkpoint and replication regulator
… yeast ortholog Dpbl 1 and the yeast protein Sld3. Consistent with this model, we show that ticrr-deficiency disrupts chromatin association of pre-initiation complex, but not prereplication complex, components in the zebrafish. The work described in this thesis demonstrates the utility of …