Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Skin permeability"”.
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Development of Knowledge Within a Chemical-Toxicological Database to Formulate Novel Computational Approaches for Predicting Repeated Dose Toxicity of Cosmetics-Related Compounds
… ingredients and related structures; (ii) skin permeability/absorption data (route of exposure relevant to cosmetics); and (iii) repeated dose toxicity data. This thesis describes the process of “knowledge discovery from the data”, including collation of the content of the COSMOS database …
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The development of a computation / mathematical model to predict drug absorption across the skin
… been a large number of studies investigating skin permeability, both experimentally- and theoretically-based. The experimental measurement of skin permeability is a time-consuming and difficu process and, when put in the context of the great numbers of chemicals that may come into contact with …
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Diffusivity of drug actives in transdermal drug delivery (TDD)
Transdermal Drug Delivery (TDD) through skin patches has many advantages including the following: slow and continuous administration of the therapeutic over long periods of time, timely dosage, accessibility, kinetic maneuverability, elimination of the "First Pass Effect" and negative side effects …
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Role of cavitation, surfactants, and their synergism in transdermal sonophoresis
… associated with phenomena that occur due to LFS skin treatment. These include a deeper understanding of: i) the reasons for heterogeneous perturbation of skin treated with LFS, ii) the physical mechanism that causes synergism between LFS and chemical penetration enhancers (CPEs), iii) the …
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Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport
… first-pass effects. However, due to the low skin permeability, transdermal drug delivery is currently limited to only a handful of drugs that are hydrophobic and of low molecular weight. The pharmaceutical relevance of many molecules that are excluded from this category, such as proteins, …
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Elucidation of chemically-induced transdermal transport processes
… many techniques currently used to increase the skin permeability to a broader range of pharmaceutically relevant drugs. By taking advantage of the current developments in instrumentation technology, the mechanisms underlying the well-known chemical enhancer action of oleic acid have been …
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An investigation of some factors affecting transdermal permeation.
… site may explain corresponding variations in skin permeability. Both hydration and type of vehicle were found to affect penetration rate. The effect of time and temperature of heat pretreatment (40°-90°C) on s.c. permeability was studied. Large increases in the permeability were obtained above …
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Integration of Data Quality, Kinetics and Mechanistic Modelling into Toxicological Assessment of Cosmetic Ingredients
… examples of models have been chosen, e.g. skin penetration and hepatic steatosis. Interpretations of models, as well as the possibility of adjustments and extensions, have been discussed thoroughly. As models usually do not depict reality flawlessly, consensus approaches of various …
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Linker-based Lecithin Microemulsions as Transdermal Drug Delivery Systems
… actives, and their ability to improve skin penetration. Lecithins (mixtures of phospholipids similar to those find in the skin) have been proposed as ideal surfactants in microemulsions due to their skin compatibility. Unfortunately, their incorporation into microemulsions used to …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… drugs involves the delivery of drugs into the skin to exert localised effects. However, relatively few drugs possess the necessary properties to passively traverse the skin and remain in the skin in a high level and long-acting way. Microneedles are a novel drug delivery technology that …
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Topical pharmacokinetics for a rational and effective topical drug development process
… data. It concludes that the knowledge of target skin tissue concentration would be key for a more rational drug development process. To this end, the primary objective of this thesis is to define a way of measuring drug concentration in skin tissue after topical application that is reliable, …
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Determination of descriptors by liquid-liquid partition and chromatographic methods
… detection threshold, nasal pungency threshold, skin permeability from water, skin-water partition coefficients, octanol-water partition coefficients, absorption by air particles, adsorption by diesel soot particles, air-water partition coefficients, and adsorption by film water).</p> <p> A …
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Use of physical enhancers for gastrointestinal and transdermal drug delivery
… treatment modality to both maximize the area of skin that is permeabilized while simultaneously minimizing the required treatment time. This new method involves the simultaneous use of low- (< 100 kHz) and high- (> 1 MHz) frequency US. A proof-of-concept of this method is presented in Chapter 2. …