Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Skin cells"”.
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Interaction of skin cells with skin microbiota
The interaction between skin cells and skin microbiota is complicated and not fully understood. A diverse community of microbes resides on the skin that participates in shaping its physiology. Skin microbiota can modulate skin immunity and barrier, thus, contributing to skin health. Also, the …
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The Effects of Radon and its Progeny on Human Skin Cells
… lung cancer, therefore its potential role in skin carcinogenesis is of interest, as Southwest England also has high skin cancer incidence. A novel radium-226 flow-through apparatus was employed to dissolve radon and its progeny into cell media. Cultured human skin fibroblasts (84BR), squamous …
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Skin cells as a tool in genetic diagnosis of Duchenne muscular dystrophy
… of D/BMD from a much less invasive shave skin biopsy. Methodologies included immunohistochemical, immunocytochemical, Western blot, qPCR analysis and cDNA sequencing. The results suggest that melanocytes and fibroblasts express the full length muscle isoform of dystrophin, although at …
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Protective Effects of Milk Phospholipids Against UV-Induced DNA Damage in Human Skin Cells
<p>Skin cancer is the most common type of cancer in the US. The American Academy of Dermatology estimated that more than 3.5 million new cases of skin cancer are diagnosed in the US each year and 1 in 5 Americans will likely to develop skin cancer in their life time. Most cases of skin cancer are …
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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
Skin cancer is the most common cancer worldwide, and its incidence rate in South Africa is increasing. Photodynamic therapy (PDT) has been shown to be an effective treatment modality, through topical administration, for treatment of non-melanoma skin cancers. Our group investigates …
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The protective effects of the antioxidant combination of ferulic acid with vitamins C and E against UV-induced photodamage in human skin cells
… in human epidermal (HaCaTs) and dermal skin cells (primary human fibroblasts (HFbs) and murine 3T3 cells). Pretreatment with the FA and vitamins C and E (vEC) combination solution reduced UVAinduced ROS in human fibroblasts while pre-treatment with vEC individually led to a reduction in …
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Investigation of the antioxidant activity of phenolic compounds in cell culture systems
… species (ROS) induced by UVA exposure of the skin. This study focuses on developing methods required to measure the effects of these synthesized compounds in ultraviolet radiation-exposed cultured skin cells. Biocatalytic synthesis of polyphenolic compounds was carried out using isolated …
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Dewdrops on the genome : regulation of gene expression by biomolecular phase separation
… of cell types - for example, neurons, immune cells, and skin cells. Each cell-type contains an identical copy of the genetic material yet performs specialized and diverse functions, in large part, due to the selective expression of particular coding DNA-elements (genes) into RNA. Mutations or …
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An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing
… wounds usually result in depigmentation of the skin. This is due to the loss of melanocytes. The lack of pigmentation in the healed wound is particularly prominent in dark-skinned individuals and could result in serious psychosocial consequences such as low self-esteem, stigmatisation and …
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Fundamentals of heterogeneous photocatalysis ; and, Consequences of inorganic and organic UV sunblocks on DNA
… designed to protect people from sunburns and skin cancers. The thesis is two-dimensional. Part A deals with fundamental studies of photocatalysis. Part B addresses more practical considerations of the use of titanium dioxide in suncreams. The thesis addresses the fundamentals of Heterogeneous …
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In situ bioprinting of the skin
… each year. Autografts and commercially available skin products are limited in size and some require a lengthy preparation time, making them unusable in severe cases that require prompt and aggressive measures to maintain the lives of wounded patients. Moreover, patient survival is inversely …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
… drives a desire to scratch. It can induce severe skin damage and critically affect psychological wellbeing (e.g., sleep-deprivation, body-image insecurity). To investigate the burden of itch, a survey was conducted with ~2500 women within the general German population, where more than one third …
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e(lasmo)DNA : the role of environmental DNA (eDNA) analysis in marine fish biodiversity assessment, with special focus on elasmobranchs
… based on the retrieval of genetic traces (skin cells, metabolic waste, etc.) naturally released in the environment, is emerging as a non-invasive method for the detection and identification of rare and elusive species in a wide range of ecosystems, including aquatic environments. My thesis …
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Dust imagined : a creative reflection on mortality, anxiety and process
Why do skin, hair and fingernails that are desirable objects, belonging to a whole body and adding to its decoration, cause disgust and become markers of mortality when they are no longer part of the living body? When disembodied and separated into single strands, skin cells and nail clippings they …
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An examination of the bioactive lipids involved in skin cell inflammation and in response to ultraviolet radiation. Effect of n-3 polyunsaturated fatty acid supplementation on red blood cell and human dermal fatty acid and production of eicosanoids by HaCaT keratinocytes and 46BR.1N fibroblasts following exposure to UVR.
… radiation (UVR) in solar light is important for skin biology. It is involved in the development acute and chronic skin inflammation, aging and cancer, causing erythema, tanning and local or systemic immunosuppression. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are considered anti- …
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The effect of UVA irradiation on the DNA damage response in a human keratinocyte cell line
… pathways play an important role in protecting skin cells against the carcinogenic effects of ultraviolet radiation (UVR). In this research project, HaCaTs were used to investigate the direct and indirect effects of UVA irradiation on the DDR. Independent inhibition of ATM and ATR prior to …
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The Role of Interleukin-10 Family Members in Inflammatory Skin Diseases. Understanding the mechanism of action of interferon lambda and interleukin-22 on human primary keratinocytes and dermal fibroblasts with a focus on healing responses in inflammatory skin diseases
… the subtype. Interferons (IFNs), including the skin specific IFNλ mainly activate STAT1, which results in inflammation in CLE and may play a significant role in scar formation in chronic discoid CLE. IL-22 activates STAT3 and it is emerging as a mediator with significant impact on normal wound …
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Strategies for Enhanced Genetic Analysis of Trace DNA from Touch DNA Evidence and Household Dust
… conglomerates, typically contain trapped shed skin cells of anyone in the vicinity along with fibers, dirt, hair, and other trace materials. Dust specimens are a potential source of forensic evidence that has been widely underutilized in the forensic community. This is unfortunate because a …
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Optimization of Gold Nanoparticles for Radiotherapy
… to be improved by better targeting of cancer cells. Improved radiotherapy outcomes can be achieved by using nanoparticles, especially those with high atomic number (Z), that interact with ionising radiation to generate secondary electrons and reactive species that increase cellular damage. One …
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PIKK-dependent activation of the DNA damage response by long wavelength ultraviolet radiation
… that increase a person’s chance of developing skin cancer. UV is divided into three subtypes, called UVA, UVB and UVC. UVA and UVB both have the ability to cause different types of DNA damage. Our understanding of UVA and its mechanism of carcinogenesis is poorly understood due to UVB being the …
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