Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Skin barrier"”.
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Skin barrier dysfunction in common genetic disorders
One of the most important roles of the skin is the formation of an effective barrier to prevent desiccation as well as to keep out foreign pathogens and allergens. This is a tightly regulated process and involves many structural proteins, lipids, enzymes and biochemical components. One of the …
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Improving the skin barrier function in atopic dermatitis
… AD (synonym eczema) is a chronic inflammatory skin disease. It affects between 10 to 20% of children and 1 to 3% of adults worldwide. It is an important cause of morbidity and is estimated to cost £465 million per annum to the UK. AD is part of a family of Th-2 driven diseases and is often the …
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Mechanistic investigation of skin barrier perturbation induced by surfactants in the presence of humectants
The stratum corneum (SC) of the skin functions as a barrier between the body and the environment. Surfactants such as Sodium Dodecyl Sulfate (SDS) are used in skin cleansers and in skin-care formulations because of their ability to stabilize oil-water emulsions and clean the surface of the skin. …
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Intrinsic alterations of the skin barrier function promote the pathogenesis of atopic dermatitis in dogs
… dermatitis (cAD) is a chronic inflammatory skin disease affecting up to 10% of the canine population, it is the second most common allergic disease in dogs. Canine AD has many similarities to human AD and for this reason the dog has been suggested to be a good animal model to study AD in …
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Staphylococci of the Skin: Consequences for Host Health
The skin is the body’s largest barrier organ, and as such hosts roughly one million bacteria per square centimeter over its 1.8m2 surface area. As a barrier organ, the skin not only provides a physical layer of defense against these microbes but an immunological one as well. Immune cells present in …
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Influence of the Autonomic Nervous System, Skin Barrier Indicators and Psycho-Emotional Aspects in Patients with Lichen Simplex Chronikus /// Влияние на вегетативната нервна система, показатели на кожната бариера и психо-емоционални аспекти при пациенти с лихен симплекс хроникус
Лихен симплекс хроникус (ЛСХ) е хронична дерматоза с ограничени, силно сърбящи лихенифицирани и инфилтрирани плаки. Предилекционно те се разполагат по задната и странични участъци на тила, по екстензорните повърхности на тялото и в ано-гениталната област. Заболяването ангажира и двата пола, като …
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The Barrier Properties of the Skin of Aquatic and Semi-Aquatic Vertebrates
Vertebrate skin is a heterogeneous organ that acts as a barrier to the external environment. A crucial structure for skin barrier function is the tight junction (TJ) complex that links skin epidermal cells. TJ proteins have been examined in mammalian skin but little is known about skin TJ proteins …
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Kultivace kožních štěpů jako modelů pro výzkum bariérové funkce kůže
… Petra Kašparová Title of the thesis: Human skin explants as models for research of skin barrier functions The skin protects the human organism from harmful environmental effects and maintains the stability of the internal environment of the human body. The protective function is considered …
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Identification and characterization of the gene responsible for the <em>matted</em> mouse phenotype
<p>The skin barrier plays an essential role in protecting the body from external assaults and maintaining homeostasis. The differentiation of keratinocytes into toughened corneocytes begins in the basal layer of the epidermis and culminates in the formation of the stratum corneum (SC). Corneocytes …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
… signaling plays a critical role in mammalian skin. Removal of Notch alleles in skin keratinocytes has been associated with an array of phenotypes with varying severity based on the identity and number of remaining Notch receptors. Phenotypes include carcinogenesis: in the case of Notch1 loss), …
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ROLE OF MICRORNAS IN THE PATHOGENESIS OF ATOPIC DERMATITIS
Atopic dermatitis (AD) is a common inflammatory skin disease, which is characterized by skin barrier defect and immune dysregulation. In this study, we investigated the role of microRNA in AD pathogenesis. We found miR-335 to be highly expressed in the differentiating layers of normal epidermis but …
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Needle-free drug delivery using shock wave techniques
… have sufficient momentum to penetrate the skin barrier and reach the viable epidermal layers. The devices offer much better control over the depth of penetration than traditional hypodermic needles, a factor particularly important in vaccine delivery. However they still have not found wide …
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Metabolic Coordination of Stem Cell Fate Controls Tumor Initiation and Tissue Repair
… cells (EpdSCs), which maintain integrity of the skin barrier over an organism's life. EpdSCs are a cell of origin for squamous cell carcinomas (SCCs), amongst the most common and threatening malignancies worldwide. Additionally, EpdSCs of the interfollicular epidermis (IFE) and hair follicle (HF) …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… is a serine protease and a pivotal regulator of skin desquamation, the physiological process of skin renewal (Brattsand et al., 2005; Borgoño et al., 2007). KLK5 is activated autocatalytically (Michael et al., 2005) and then, it activates other downstream proteases that are expressed in the …
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The Impact of Psychological Interventions on Wound Healing
… showed that a relaxation intervention improved skin barrier recovery after tape stripping regardless of whether it was performed before or after the injury. It also identified that pain and sleep are important in wound healing. The second study (Study 2) found that an expressive writing …
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QSAR modeling of chemical penetration enhancers using novel replacement algorithms
… are limited because of the resistance of the skin to drug diffusion. Only potent drugs, with molecular weight less than 500 Da, are suitable to cross the skin barrier. Chemical Penetration Enhancers (CPEs) are used to promote the absorption of solutes across the dermal layers. In this …
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Splits and integrations: A phenomenological exploration of self-harm marks and scars
What happens after the skin barrier has been broken? This study explores the experience of having marks and scars on the body as a result of self-harm. It aims to investigate the meaning attributed to the marks and scars on the body and how they shape the experience of self-harm and identity of the …
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Elucidation of chemically-induced transdermal transport processes
… many techniques currently used to increase the skin permeability to a broader range of pharmaceutically relevant drugs. By taking advantage of the current developments in instrumentation technology, the mechanisms underlying the well-known chemical enhancer action of oleic acid have been …
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Expression and function of small RNAs in normal and psoriatic skin
Psoriasis is a chronic, inflammatory skin disease characterized by hyperproliferation and altered differentiation of keratinocytes, and infiltration of activated immune cells in the epidermis. Array based genome-wide expression studies by our lab and others have revealed over 1,300 alterations in …
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