Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Skin absorption"”.
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Effect of formulation factors on the skin penetration of drugs
Permeation of chemicals through skin can lead to systemic effects of drugs or toxic exogenous chemicals. Skin permeation of compounds and the effect of mixture ingredients can be related to their chemical structures as expressed by molecular properties. This approach, known as Quantitative …
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A novel encapsulation favorably modifies the skin disposition of topically-applied N,N-diethyl-3-methylbenzamide (DEET)
The skin disposition of the insect repellent N,N-diethyl-3-methylbenzamide (DEET) was modified using a unique encapsulation method. Incorporation of DEET into a controlled-release microcapsule facilitated a decrease in skin absorption compared to a DEET in ethanol control while evaporation rates …
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In vitro studies of dermally absorbed Cu(II) tripeptide complexes as potential anti-inflammatory drugs
… the bioavailability of copper(II) through dermal absorption. Glass electrode potentiometry was used to measure the solution thermodynamics of copper(II), nickel(II) and zinc(II) with Gly-Leu-Phe and Sar-Leu-Phe, at 25 0.01 °C and an ionic strength of 0.15 M (NaCl). The terminal amine of both …
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Development of copper peptide complexes as anti-Inflammatory drugs
… weight Cu(II) species in vivo is via dermal absorption. For this reason the drugs were designed so that they could be administered dermally and be selective for Cu(II) so that they do not affect the speciation of other metal ions in blood plasma. Speciation calculations of Cu(II) using a …
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Development of an analytical method to derive hydrophobicity parameters for use as descriptors for the prediction of the environmental and human health risk of chemicals
… predict the ability of a chemical to cross the skin barrier and to predict various acute aquatic toxicity endpoints, using published skin absorption and ecotoxicity data respectively.
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The development of a computation / mathematical model to predict drug absorption across the skin
… been a large number of studies investigating skin permeability, both experimentally- and theoretically-based. The experimental measurement of skin permeability is a time-consuming and difficu process and, when put in the context of the great numbers of chemicals that may come into contact with …
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An investigation of in vitro percutaneous penetration enhancement of benzocaine by azone, dimethylsulfoxide, and 2-pyrrolidone
… utilizing full thickness human abdominal skin was designed to assess the in vitro percutaneous penetration of benzocaine by 1-dodecylazacycloheptan-2-one (Azone) , dimethylsulfoxide (DMSO) and 2-pyrrolidone (2-P) under conditions of constant thermodynamic activity in the vehicle. The …
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A comparative study on the effectiveness of application techniques of tissue oil enriched with Rooibos (Aspalathus Linearis) extract on dehydrated skin of women aged between 18 and 45 years
Submitted in fulfilment of the requirements of the Degree of Master of Technology: Somatology, Durban University of Technology, Durban, South Africa, 2019.
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The damaging potential of pesticide formulations on human skin
Percutaneous absorption is the major route of pesticide entry into the body. Impairment of skin barrier function may increase systemic exposure and toxicological risk. This project examines barrier function impairment of human skin in vitro due to commercial liquid formulations of the pesticides …