Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 106 for “"Skeletal muscles"”.
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Microtubule Regulation of Mitochondrial Bioenergetics in Cardiac and Skeletal Muscles
… has yet to be demonstrated in cardiac and skeletal muscles, particularly in relation to mitochondrial bioenergetics. The primary objective of this thesis was to explore the tubulin-VDAC model of mitochondrial bioenergetic regulation in cardiac and skeletal muscles. This was achieved by …
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Effects of Occlusal Splints and Occlusal Equilibration on Skeletal Muscles in TMJ Patients
… position does not affect the performance of skeletal muscles, and that mouthguards or orthopedic repositioning splints used to alter mandibular position are nothing more than expensive placebos. These critics state that there is no scientific evidence to support claims of increased athletic …
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Demonstration and quantitation of lactate in oxidative and glycolytic fibers of skeletal muscles
… $\sp1$H NMR spectroscopic studies of fatiguing skeletal muscles. They are typically 15-20 Hz apart at 300 MHz. Known resonances in this region include lactate, alanine, threonine, and the acyl chain of lipid. From both NMR evidence (COSY, lactate editing, and $\sp{13}$C enrichment) and …
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A study of biochemical and physiological properties of normal and functionally impaired skeletal muscles
… understanding of the diversity and plasticity of skeletal muscle by using (i) normal and functionally impaired rat muscles from normotensive and spontaneously hypertensive rats, (ii) single, skinned fibre preparations, and (iii) a combination of biochemical [SDS-polyacrylamide gel electrophoresis …
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Expression and Putative Functions of Fibroblast Growth Factor 10 (Fgf10) in Developing and Adult Skeletal Muscles
… the discovery of Fgf10 expression in adult mouse skeletal muscles. Using an Fgf10-nLacZ reporter line, I set out to characterize this novel expression pattern in order to learn more about Fgf10’s putative function/s. I have shown that intriguingly Fgf10 is only expressed in a subset of adult …
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Verification of the Existence of a Soluble Relaxing Factor in Phasic and Tonic Vertebrate Skeletal Muscles
Made available in DSpace on 2014-12-09T23:33:57Z (GMT). No. of bitstreams: 1 6706620.pdf: 4798817 bytes, checksum: d13cb7baa6b76c32607f90e5c4b8a5fb (MD5) Previous issue date: 1966
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Structural and contractile alterations in skeletal muscles from the genetically obese (ob/ob) mouse: impairment or adaptation?
… often reported to exhibit marked reductions in skeletal muscle size, but currently available data on the contractile function of skeletal muscles in rodent models of obesity are scarce and often conflicting. Therefore, the overall aim of this study was to further knowledge and understanding of …
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The role of Calcineurin in skeletal muscle differentiation
… muscle fibers compared to slow-twitch in resting skeletal muscles. Activation of the Calcineurin in 4 skeletal muscle myocytes selectively up-regulates slowfiber- specific gene promoters through a mechanism involving the transcription factor NFATcI. The Calcineurin pathway itself was …
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Feasibility study in using intelligent-materials to create actuators with muscle capabilities that can enhance prosthetics
… with similar capabilities and functionality as skeletal muscles, where none yet has obtained a broader use. Intelligent materials show great potential in creating new actuators. Previous attempts in creating muscle similar actuators have in general been an effort of material science, resulting …
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Expression and functional analysis of murine ryanodine receptor type 3
… and RyR3. RyRl and RyR2 are highly expressed in skeletal and cardiac muscles respectively, where they localize in the terminal cisternae of the sarcoplasmic reticulum (SR). Although RyRl and RyR2 have been found to be expressed in several other tissues at much lower level than in striated …
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Probabilistic methods applied to fluctuating systems
… The second system investigates the disorders of skeletal muscles and the nervous system by considering the fluctuation of electric potentials of skeletal muscles. The last system studied is a non-physical system where price increments are used to classify the financial markets in terms of …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… drive distinctive programs of gene expression in skeletal muscles, thereby establishing a high degree of metabolic and physiological specialization among myofiber subtypes. Previous studies have demonstrated that calcineurin activity is required to maintain slow myofiber identity. I am interested …
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Targeting transcriptional and translational mechanisms to enhance utrophin A expression as a therapy for Duchenne muscular dystrophy
… mutations/deletions in the dystrophin gene. In skeletal muscle, dystrophin is expressed along the sarcolemma, providing a mechanical link between the cytoskeleton and the extracellular matrix; loss of dystrophin results in disrupted sarcolemmal integrity and progressive muscle wasting. Utrophin …
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The role of Lynx1, an endogenous modulator of cholinergic transmission, in NMJ development, maintenance, and repair
… of mammalian neuromuscular junctions (NMJs) and skeletal muscles. Because of these essential actions, much effort has been devoted to identifying primary and auxiliary modulatory components of the cholinergic system at NMJs and throughout skeletal muscles. Here, I asked if Lynx1, a GPI-anchored …
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In Vitro and In Vivo Effects of Leucine on Skeletal Muscle Protein Synthesis and Degradation
The regulatory role of leucine in skeletal muscle protein synthesis and degradation was examined using in vitro and in vivo experimental methods. Two skeletal muscles from young Sprague-Dawley rats were used in all experiments. These muscles were the soleus, a slow-twitch, oxidative muscle and the …
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Skeletal Muscle and Post-Heparin Plasma Lipoprotein Lipase Activities (Exercise, Triglyceride)
… The LPL activity of adipose tissue, but not skeletal muscle, has been studied extensively. Although a quantitative relationship between LPL activity, plasma TG levels and the rate of plasma TG removal has not been substantiated, subtle changes in the LPL activities of specific tissues are …
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Characterizing PDK4 and PKC-Theta in Pancreatic Cancer and Cachexia
… Kinase 4 (PDK4) is upregulated in the skeletal muscles of many cancer cachexia models and has been shown to drive muscle wasting in some conditions. We show that despite being upregulated in an orthotopic mouse model of PDAC cachexia, whole-body deletion of PDK4 did not prevent the …
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The Cellular Basis for Skeletal Muscle Growth Retardation (Undernutrition)
… cells, use of this technique for tissues (e.g. skeletal muscles) with multinucleated cells may not be appropriate. The primary purpose of the present research was to re-evaluate the cell number/cell size hypothesis and its application to skeletal muscle. Biochemical and morphological …
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Growth factors in extraocular muscles: effects on contractile properties
Extraocular muscles are a unique group of skeletal muscles, with distinct biological properties, including specialized myofiber types, a unique transverse and longitudinal organization of myofibers, continued muscle plasticity and the retention of activated progenitor cells in adult normal muscles. …
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