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Showing 1 to 20 of 23 for “"Skeletal Muscle Regeneration"”.
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Cellular and molecular regulation of skeletal muscle regeneration
<p>Skeletal muscle regeneration provides a powerful model to study the cellular and molecular mechanism governing stem cell function since the whole process is mediated by a population of muscle-resident stem cells called satellite cells. The overall aim of this dissertation is to explore the roles …
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The Role of Oxidative Stress in Skeletal Muscle Regeneration
… tissue involves the coordinated activities of muscle precursor cells (MPCs) in response to local and systemic signals. Following tissue injury, the microenvironment, which is characterized by excessive production of reactive oxygen species (ROS), is attenuated. Here we studied the efficacy of …
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The Role of Ring1 and Rnf2 in Skeletal Muscle Regeneration
The skeletal muscle environment is highly complex, with inputs from multiple cell types and environmental challenges in homeostatic and regenerative conditions. Satellite cells, a population of quiescent adult stem cells, maintain the regenerative potential of muscle well into adulthood, but the …
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THE EFFECT OF SDF1α ON SKELETAL MUSCLE REGENERATION AFTER COMPARTMENT SYNDROME INJURY
Introduction: Skeletal muscle dysfunction, whether due to injury, disease or age, can be debilitating to normal life. There are few effective treatments for severe skeletal muscle injuries. SDF1α is a chemokine which promotes migration of stem cells through binding to the CXCR4 receptor and has …
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T cell mediated satellite cell function: implications for age-associated changes in skeletal muscle regeneration
Sarcopenia is an age-associated loss of skeletal muscle mass and strength. Recent evidence suggests that an age-associated loss of muscle precursor cell (MPC) functionality contributes to sarcopenia. Current research also suggests that T cells of the immune system may influence skeletal muscle …
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The Effects of Chronic Prophylactic Naproxen Sodium on Skeletal Muscle Adaptation to Resistance Exercise in Recreationally-Trained College-Aged Males
Resistance exercise causes exercise-induced muscle injury (EIMI), triggering an acute local inflammatory response associated with delayed-onset muscle soreness (DOMS). DOMS is characterized by a predictable discomfort and decreased level of muscle performance and is believed to be the product of …
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Mechanisms of mTOR Signal Transduction Regulating Cell Growth and Differentiation
… from the microarray analysis, we focus on the muscle-specific miR-1, which is up-regulated during differentiation. mTOR is essential for miR-1 expression in C2C12 cells and in vivo in regenerating myofibers. It regulates the transcription of miR-1 through its upstream enhancers, and this …
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Non-canonical functions of leucyl-tRNA synthetase: Mechanism of cell growth and skeletal myogenesis
… in cell growth, myogenic differentiation, and skeletal muscle regeneration. Amino acid availability activates signaling by mTORC1. The class III PI-3-kinase Vps34 mediates amino acid signaling to mTORC1 by regulating lysosomal translocation and activation of the phospholipase PLD1. In …
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Stimulation de la régénération endogène dans le traitement de la dystrophie musculaire
… exist. These diseases are characterized by muscle wasting, limited life expectancy and reduced ambulatory capacities. Mutations in proteins implicated in the attachment of muscle fibers to the extracellular matrix cause the fibers to be more fragile, making them more susceptible to rupture …
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Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity
PW1+/Pax7– skeletal muscle-derived interstitial progenitor cells (PICs) are myogenic in vitro, efficiently contribute to skeletal muscle regeneration in vivo, and are self-renewing in vivo whilst also giving rise to satellite cells (Mitchell et al. 2010). They have previously been identified in the …
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The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
… could be essential for tissue development and regeneration. Previous results have also indicated that inhibition of PGE₂ synthesis through the cycoloxygenase-2 (COX-2) pathway at an early stage of muscle recovery from damage attenuated skeletal muscle regeneration. However, the exact mechanisms …
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Development and Characterization of Tunable, Bioinspired Electrospun Constructs for Skeletal Muscle Engineering
Volumetric muscle loss, as a result of high intensity sports injury, trauma or tumor ablation, affects more than 250,000 civilians each year in the U.S. alone and accounts for more than 50% of all DoD disabilities. These injuries often leave patients with permanent structural and functional …
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Elucidating Functional Roles For Myogenin In Adult Skeletal Muscle Metabolism, Exercise Capacity, and Regeneration
… Myf5, MRF4, and MyoD are critical for embryonic skeletal muscle development. Myogenin is necessary for the terminal differentiation of myoblasts into myofibers during embryogenesis, but little is known about the roles played by myogenin in adult skeletal muscle function and metabolism. …
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Targeting transcriptional and translational mechanisms to enhance utrophin A expression as a therapy for Duchenne muscular dystrophy
… mutations/deletions in the dystrophin gene. In skeletal muscle, dystrophin is expressed along the sarcolemma, providing a mechanical link between the cytoskeleton and the extracellular matrix; loss of dystrophin results in disrupted sarcolemmal integrity and progressive muscle wasting. Utrophin …
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Functional Genomics Characterization of Six4 During Skeletal Myogenesis
Adult skeletal muscles can regenerate after injury due to the presence of satellite cells, a quiescent population of myogenic progenitor cells characterized by expressing the transcription factor Pax7. Once activated, satellite cells repair the muscle damage and replenish the stem cell niche due to …
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MEF2-regulated Gtl2-Dio3 noncoding RNAs in cardiac muscle and disease
… transcription factor is a central regulator of skeletal and cardiac muscle development. Recently, we showed that MEF2A regulates skeletal muscle regeneration through direct regulation of the Gtl2-Dio3 microRNA mega-cluster. In addition to their expression in skeletal muscle, temporal expression …
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The Role of Vitamin D in Skeletal Muscle Function and Regeneration
Skeletal muscle is a direct target for the group of seco-steroids collectively termed Vitamin D. Skeletal muscle expresses both CYP27A1 and CYP27B1 encoding for the hydroxylases required to convert Vitamin D to 25[OH]D and subsequently the bioactive 1α-25-dihydroxyvitamin D3 (1α-25[OH]2D3) (Girgis …
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Development of novel strategies to improve skeletal muscle repair and adaptation following eccentric exercise
… as well as daily activities, can injure skeletal muscle. The repair of muscle damage is essential for effective remodeling, tissue maintenance, and initiation of beneficial adaptations post-exercise. We have previously demonstrated that transgenic overexpression of the α7BX2 integrin in …
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Muscle-derived cytokines: novel regulators of skeletal myogenesis
Mature skeletal muscle has a uniquely robust capacity for regeneration. This ability is due in large part to the resident population of muscle stem cells in the tissue, known as satellite cells. These adult stem cells reside in a quiescent state near the basal lamina of skeletal myofibers, but are …
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Muscle cell-derived cytokines in muscle regeneration
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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