Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Skeletal Muscle Hypertrophy"”.
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The Effect of Hyperthermic Whole Body Heat Stimulus (Sauna) on Heat Shock Protein 70 and Skeletal Muscle Hypertrophy in Young Males during Weight Training
… Finnish steam sauna is theorized to aid skeletal muscle hypertrophy by stimulating Heat Shock Protein 70 (HSP70), which acts as a molecular chaperone to the folding of functional skeletal muscle. The aim of this study was to investigate if stimulating HSP70 by using a sauna (45 – 50 ͦC, …
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Gene expression profiling of myostatin null mice
Increasing muscle growth is beneficial to the meat animal industry and for biomedical research. Altering myostatin function and administration of β-adrenergic agonists, such as clenbuterol, enhances muscle growth. However, it is unclear whether the mechanisms of these effects converge in a single …
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mTOR Signaling in Cellular Growth and Skeletal Muscle Maturation
… S6K1 homologue, S6K2, and for the regulation of skeletal muscle myotube growth. My results showed that S6K2 requires mTOR and its kinase activity for its activation. Amino acid and nuclear-cytoplasmic shuttling of mTOR were shown to be required for S6K2 activation. Skeletal myogenesis is a …
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Effects of Resistance Training on aged Skeletal Muscle and Mitochondrial Function
… of our population. Aging brings about changes in skeletal muscle such as reduced muscle strength and mass, as well as cellular deficits such as increased production of reactive oxygen species (ROS), and mitochondrial DNA (MtDNA) deletions and mutations. Muscle mass declines at a rate of 1-2% each …
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The Role of DNA Methylation in the Regulation of Skeletal Muscle Atrophy, Hypertrophy and Epigenetic ‘Memory’
Skeletal muscle mass is vitally important for the maintenance of health and quality of life into old age, with a plethora of disorders and diseases linked to the loss of this tissue. As a consequence, molecular biologists have extensively investigated both atrophying and hypertrophying skeletal …
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Examining the Influence of Muscle Fiber Type on Protein Turnover Signaling in Growing Pigs
Postnatal skeletal muscle growth occurs through myonuclear accretion and high protein turnover rate. While fiber type composition of the muscle could affect protein turnover rate, less is known about how fiber type influences the regulation of protein synthesis and degradation signaling pathways. …
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The differential Role of Insulin-like Growth Factor-1 Isoforms in Skeletal muscle
… and differentiation, and plays a major role in hypertrophy and tissue remodeling in the fetal, perinatal, and adult organism. In skeletal muscle the role of IGF-1 is well established, but questions remain about the significance of the various isoforms that are produced from the single-copy IGF-1 …
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NOVEL ROLES FOR GRK2 IN METABOLIC HOMEOSTASIS AND SKELETAL MUSCLE PHYSIOLOGY
… little is known about the role of GRK2 in skeletal muscle function and disease. In the first study of this dissertation, we generated a novel skeletal muscle specific GRK2 knockout (KO) mouse (MLC-Cre:GRK2fl/fl) to gain a better understanding of the role of GRK2 in skeletal muscle …
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Glucose Metabolism in Low Birth Weight Neonatal Pigs
… by high growth rates and is dominated by skeletal muscle hypertrophy. Low birth weight (LBWT) neonates experience restricted growth and development of skeletal muscle, leading to metabolic perturbations later in life. The overall hypothesis of this dissertation was that in utero …
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Energy metabolism in skeletal muscle: mechanistic insights into mitochondrial function and growth
Skeletal muscle metabolism is critical to understanding the efficiency of muscle growth for the global meat industry. As such, there are many contributing factors that can influence muscle growth yet there are still basic molecular mechanisms that remain unexplored. Specifically, the involvement of …
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EFFECTS OF EXERCISE PRECONDITIONING ON MUSCLE HYPERTROPHY AND MITOCHONDRIAL REMODELING FOLLOWING THE SUBSEQUENT RESISTANCE TRAINING
… with a previous training history acquire muscle volume at an accelerated rate. This phenomenon may be attributed, in part, to the myonuclear enrichment resulting from the proliferation of muscle progenitor cells, which promotes essential protein synthesis following subsequent muscle …
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Skeletal muscle adaptations in cachectic, tumor-bearing rats
… body wasting, primarily due to the loss of skeletal muscle mass. This study tested the hypothesis that muscle atrophy associated with cancer cachexia could be attenuated by using a unilateral, functional overload (FO) model applied concurrently with tumor development. To accomplish this, …
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The Effects of Resistance Wheel Running on Skeletal Muscle Function and Adaptation in C57BL/10SnJ Mice
… resistance-like training adaptations in mouse skeletal muscle (SkM), but its endurance-training effects are lesser known. Methods: Voluntary RWR was modulated as an exercise model to increase mouse hind-limb plantar-flexor torque and to promote endurance-training adaptations. Thirty male mice …