Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Skeletal Muscle Cell"”.
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Nutritional Manipulation of Exercise Induced Skeletal Muscle Cell Signalling: Implications for Acute Training Adaptations
… training-induced oxidative adaptations of skeletal muscle, the so-called train-low paradigm. In accordance with this movement there is also growing rationale ot consume protein before, during and/or after train-low sessions in an attempt to simultaneously promote mitochondrial biogenesis, …
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Fractionation and compositional studies of rabbit skeletal muscle membranes
… Virchow (1855) led to the identification of the cell as the basic structural unit of living material. In the intervening years, it has been firmly established that the chemical processes which underlie the proper functioning, development and reproduction of the organism are cellular activities. …
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Fabrication and integration of graphene field effect transistors for advanced biosensing platforms
… show versatility of a graphene FET device with cellular interfaces, I carried out in vitro study of a non-spontaneous cell-type, skeletal muscle cell (C2C12) using a multi-array graphene FET. In this investigation, I demonstrated simultaneous stimulation and rapid electrical sensing of C2C12 …
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Pathways of intracellular protein degradation in cultured muscle cells
… responsible for the turnover of endogenous muscle protein, lysosomotropic proteinase inhibitors have been employed to elucidate the relative contributions of lysosomal and non-lysosomal degradation pathways functioning under varying nutritional states and for different classes of …
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The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
… survival and proliferation of hematopoietic stem cells, suggesting that PGE₂ signaling could be essential for tissue development and regeneration. Previous results have also indicated that inhibition of PGE₂ synthesis through the cycoloxygenase-2 (COX-2) pathway at an early stage of muscle …
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Exploring the impact of osteoporosis on myogenesis
… in bone mass and strength (osteoporosis) and in muscle mass and strength (sarcopenia). These conditions pose a tremendous threat as each year, one in three older adults living in the community falls. Muscle weakness is a primary risk factor for falls and the associated morbidity and mortality, …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… Models used for investigation included the L6 skeletal muscle cell line and isolated skeletal muscles. In vivo studies were undertaken to investigate glycaemia, insulinaemia, satiety and body weight in streptozotocin-induced diabetic mice and obese (ob/ob) mice. Leptin acutely altered insulin …
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Keratin Microparticles for Drug and Cell Delivery
… are an intriguing delivery vehicle for drugs and cellular payloads for tissue engineering purposes due to the ability to exploit size, surface area, loading potential and importantly, non-invasive delivery (i.e. injection) of cells and biologics. Here we examine the water-in-oil emulsion synthesis …
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Influence of biological sex and thyroid hormone on skeletal and cardiac muscle metabolism in heat-stressed pigs
… warming temperatures caused by climate change. Skeletal muscle, which is the main source of income for the meat industry, is particularly sensitive to HS. Lean tissue accretion declines during HS, in part because of inefficient metabolism and altered metabolic flexibility. The first study …
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The Influence of Insulin-like Growth Factor Pathway Gene Polymorphisms on the Strength Training Response of Muscle Phenotypes in Older Adults
… growth factor 1 (IGF1) gene influenced the muscle strength response to ST in Caucasians. Other studies have shown that the insulin-like growth factor binding protein-3 (IGFBP-3) is a modulator of IGF-1 in circulation and is present in skeletal muscle. The -202 polymorphism in the promoter …
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THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
The skeletal muscle of severely obese individuals (BMI > 40 kg/m²) is characterized by a depressed ability to oxidize fatty acids and a failure to upregulate fatty acid oxidation (FAO) in response to increased lipid availability, both of which may contribute to a positive lipid balance and weight …
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Exercise-induced cell signalling responses of human skeletal responses of human skeletal muscle: the effects of reduced carbohydrate availability
… that regular endurance exercise induces skeletal muscle mitochondrial biogenesis. However, the optimal training stimulus and nutritional intervention for which to maximize mitochondrial adaptations to endurance exercise is not well known. Developments in molecular techniques now permit …
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Fabrication and Optimisation of Collagen Scaffolds for Muscle Cell-Supported Angiogenesis
… scaffolds capable of supporting differentiated muscle cell populations with the potential for vascularisation. Collagen I scaffolds with varying internal architectures were fabricated and characterised, cell-material interactions were assessed in both 2D and 3D, and human dermal microvascular …
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Genetic investigation of recurrent exertional rhabdomyolysis risk and performance in racehorses
… racehorses involving repeated episodes of skeletal muscle cell breakdown in response to exercise in otherwise physically fit horses. Based on epidemiological and heritability studies, RER has been hypothesized to be a complex polygenic disease with significant sex and environmental …
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Identifying circulating biomarkers in a cohort of hypercholesterolaemic patients with statin intolerance from Gauteng, South Africa
… statin associated adverse effects, especially muscle related symptoms. Studies suggest that statins affect hundreds of miRNAs, as one miRNA has the potential of binding to hundreds of mRNAs, the consequences may be enormous. However, whether these epigenetic changes lead to statin related …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… flow, paw size, number of necrotic toes, or skeletal muscle cell size. We conclude that FAV and FA excision in CD-1 mice generate a comparable severity of hindlimb ischemia. In other words, FAV ligation is no more severe than FA ligation. These findings provide valuable information for …
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Nutritional Supplementation and Skeletal Muscle Health in Chronic Diseases
… This thesis mainly focuses on obesity and aging. Skeletal muscle performance is impaired in obesity and aging conditions. One common reason causing this could be higher fat mass and lower muscle mass. However, there is no study showing what pathways are involved in the imbalance of body …