Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2029 for “"Skeletal"”.
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The Effects of Zinc on Skeletal Alkaline Phosphatase Activity and Skeletal Tissues
<p>Zinc is essential for normal growth, however, very little is known about the mechanisms by which zinc influences growth. ALP, an ectoenzyme expressed in high levels in osteoblasts, is a zinc-containing metalloenzyme and is important in bone formation. Preliminary studies showed that low levels …
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Biofunctional hydrogels for skeletal muscle constructs
Skeletal muscle tissue damage costs the US government hundreds of billions of dollars annually. Meanwhile, there is great potential to use skeletal muscle as a scalable actuator system, covering wide length scales, frequencies, and force regimes. Hence, the interest in soft robotics and …
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Force response of locust skeletal muscle
… no broadly valid method of modelling skeletal muscle exists. Studies that compare the merits of existing models are extremely scarce and researchers make various assumptions in order to simplify the complex, nonlinear behaviour of the muscle. Locusts provide an opportunity to develop a …
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ROLE OF G9A IN SKELETAL MYOGENESIS
… that mutations in sarcomeric proteins underlie skeletal muscle disease and dysfunction. Here, we provide evidence that the lysine methyltransferase G9a represses expression of several sarcomeric genes, whereby over-expression of G9a disrupts sarcomere integrity of skeletal muscle cells. This …
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Cryopreservation of tissue engineered skeletal muscle
Tissue engineered skeletal muscle plays an important role not only in the field of regenerative medicine, but also in emerging areas such as soft robotics, organ-on-a-chip models of disease, and drug testing. However, further expansion of the applications of tissue engineered skeletal muscle models …
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The Satellite Cell of Skeletal Muscle
This thesis is centred on a unique feature of the skeletal muscle fibre, the satellite cell. This small fusiform cell, lying in a subsarcolemmal position, is the most recently discovered cytological entity of skeletal muscle. It can be readily distinguished from other better-known mononuclear cells …
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Skeletal adaptation to reduced mechanical loading
… rest. The overall goal of this work was to study skeletal adaptation to varying amounts of reduced loading to help delineate the relationship between mechanical stimuli and skeletal adaptation. We first examined the relative contribution of muscle and gravitational forces to the maintenance of …
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Skeletal adaptation to reduced mechanical loading
… rest. The overall goal of this work was to study skeletal adaptation to varying amounts of reduced loading to help delineate the relationship between mechanical stimuli and skeletal adaptation. We first examined the relative contribution of muscle and gravitational forces to the maintenance of …
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The Biomechanics of Thoracic Skeletal Response
… novel material, structural, and global thoracic skeletal response data as well as quantify thoracic injury timing in both frontal belt loading and side impact tests using cadaveric specimens.
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Postmortem metabolism in porcine skeletal muscle
Once an animal is harvested for meat, skeletal muscle attempts to maintain ATP at or near antemortem levels. To maintain ATP levels postmortem, stored glycogen is catabolized to produce ATP through glycolysis and possibly oxidative metabolism. Hydrolysis of the produced ATP acidifies muscle until …
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Does Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?
The skeletal muscle is a highly plastic tissue that is able to adapt to changes from different stressors such as exercise. Angiogenesis is the formation of new capillaries from existing vessels; allowing for better blood flow to the working skeletal muscles. Epigenetic modifications support changes …
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Simulating Blast Effects In Steel Skeletal Structures
… the consideration of blast effects in steel skeletal structures composed of wide-flange members. This research is split into three main parts: (1) development of an air blast load generation code, derived from openly available sources, to calculate spatially and temporally varying blast loads …
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Matrix-mediated formation & innervation of skeletal myotubes
… matrices for the formation and innervation of skeletal muscle. This thesis discusses the development of advanced bioactive matrices to be able to study the role of a variety of extracellular matrix properties on skeletal muscle formation and, ultimately, innervation. The role of polysaccharide …
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Regulation of Glycogenolysis in Anaerobic Skeletal Muscle
Functional compartmentation of anaerobic metabolism was demonstrated in intact tissue. Force-independent ATP utilization, primarily the Ca 2+ pump of the sarcoplasmic reticulum, preferentially uses ATP derived from glycogenolysis. ATP produced by creatine kinase is used mostly by force-dependent …
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Factors Affecting Skeletal Metabolism in Aging Mice
Made available in DSpace on 2014-12-09T14:28:48Z (GMT). No. of bitstreams: 1 6503671.pdf: 3762418 bytes, checksum: 6b73d456af26bfa9685e0d08f5d1143d (MD5) Previous issue date: 1964
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Aberrant Ras/MAPK signaling in skeletal development
… these developmental syndromes is a defect in the skeletal development of the patients. However, the in vivo role of MAPK signaling during bone development is still controversial, with some studies supporting a positive role of the MAPK pathway during this process, and others arguing for a …
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E2F6 in axial skeletal development and gliosis
… Loss of E2f6 results in posterior axial skeletal transformations. Mice deficient for both E2f6 and Bmil, a component of PRC1, exhibit increased penetrance of axial skeletal transformations. Thus, E2F6 and Bmil cooperate in the regulation of Hox genes and axial skeletal development. Bmi 1 …
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Mechanical Properties of Maturing Dystrophic Skeletal Muscle
… of maturing dystrophic compared to control skeletal muscle membranes are weaker, leading to onset of Duchenne muscular dystrophy (DMD). We built on a previous report from our lab that suggested sarcolemmal membranes from dystrophic mice are not more susceptible to damage early in maturation …
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Selected skeletal alteration to improve beef tenderness
A pre rigor cut was made through the 12th thoracic vertebrae of one side of a beef carcass, while the other side, processed conventionally, served as the control. The effect of this cut upon yield grade, sensory attributes and tenderness of Longissimus steaks was determined. The treatment caused no …
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