Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Sjögren’s syndrome"”.
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Somatic Mutations in Primary Sjögren’s Syndrome
Somatic Mutations in Primary Sjögren’s Syndrome Aleksandra Ivovic Despite decades of research and many insightful findings, a complete understanding of the pathogenesis of autoimmune diseases continues to elude us. In this thesis, I explore the hypothesis that somatic mutations may underpin the …
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Avaliação das galectinas 1 e 3 séricas e salivares em pacientes com Síndrome de Sjögren primária e sua associação com manifestações clínicas da doença
A Síndrome de Sjögren Primária (SSP) é uma doença autoimune complexa e heterogênea caracterizada por infiltração linfocítica principalmente em glândulas salivares e lacrimais. Os objetivos do trabalho foram avaliar os níveis de galectinas 1 (Gal-1) e 3 (Gal-3) séricas e salivares em SSP e sua …
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Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases
… is challenged by findings in cases of primary Sjögren’s syndrome (pSS), who do not express ACPA, but who have been reported to carry anti-PAD. Objectives: Reproducing the study claiming the presence of anti-PAD in pSS. Screening for ACPA and antibodies against TG2 and PAD in pSS (n=78), …
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Autonomic dysfunction in primary Sjögren's syndrome
… dysfunction (AD) in patients with primary Sjögren’s syndrome (pSS) and to evaluate its clinical associations. In study I, 46 pSS patients and 56/80/238 autonomic nervous function test (ANT) controls participated. Objective signs of AD were evaluated using three different cardiovascular ANTs …
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The role of clinical, biological, and socioeconomic factors on the development of resilience in women with autorimmune rheumatic diseases : a cross-sectional study
… erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS) and systemic sclerosis (SSc). METHODS: A cross-sectional study in 188 women with SLE (n= 70), RA (n= 51), SS (n= 32), and SSc (n= 35) was done. Resilience was evaluated by the “Brief Resilience Scale”, whereas independent …
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Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)
… symptoms and dysmotility. In primary Sjögren’s syndrome (pSS), a patient group with high levels of GnRH antibodies, associations between objective signs and symptoms of autonomic dysfunction (AD), impaired gastric emptying (IGE), and inflammatory and serological features were studied. …
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Genomic investigation of primary immunodeficiency
… and autoimmunity, predominantly early-onset Sjögren’s syndrome. Reduced tumour necrosis factor receptor-associated factor 3 (TRAF3) in B cells led to increased NF-B2 activity resulting in polyclonal hypergammaglobulinaemia and auto-antibody production. Increased NF-B2 activity promoted …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… incidence of inflammatory pathology resembling Sjögren’s syndrome, characterised by lymphocytic infiltrates in salivary glands and liver of 8-10 month old CCX-CKR⁻/⁻ mice. Previous work has implicated CCX-CKR as an important regulator of CCL19 and CCL21 in vivo and deletion of CCX-CKR led to …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… (SLE), rheumatoid arthritis (RA) and the primary Sjögren’s syndrome (pSS) decrease life quality of patients and can lead to life threatening events such as lupus nephritis [1]. Recognition of self-antigens by the B cell receptor (BCR), development of autoimmune memory and beneficial therapeutic …