Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Site-specific Protein Modification"”.
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Studies and applications of protein prenylation using isoprenoid analogues and site-directed mutagenesis
The site-specific enzymatic modification of proteins offers a powerful tool both for the development of new research techniques and for the development of more effective therapeutics. Protein farnesyltransferase (PFTase) is a promising tool in the field of site-specific protein modification due to …
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Multifunctional Chemical Cross-linkers for Drug Carriers and Molecular Probes
… bioconjugates. We develop a new strategy for the site-specific modification of native antibodies. This strategy enables dual “click” modification of native antibodies. We also develop new synthetic methods for the synthesis of oligothioetheramides. We apply this new synthesis to study the effect …
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DNA enzymes for peptide-nucleic acid conjugation and for lysine methylation
Proteins and RNA are known to be enzymes in nature. These biopolymers have complex secondary and tertiary structures that can enable substrate binding and catalysis. DNA is primarily double-stranded and is not known to be catalytic in nature. However, given the similarities in chemical structure …