Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Sister chromatid exchanges"”.
-
ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΩΝ ΕΠΙΔΙΟΡΘΩΤΙΚΩΝ ΜΗΧΑΝΙΣΜΩΝ ΤΟΥ DNA ΣΕ ΛΕΜΦΟΚΥΤΤΑΡΑ ΑΤΟΜΩΝ ΜΕ ΣΥΝΔΡΟΜΟ DOWN
… THREE DIFFERENT METHODS, NAMELY: 1) BY COUNTING SISTER CHROMATID EXCHANGES (SCE) IN NORMAL AND DOWN CELLS WHICH WEREFOUND OF SIMILAR LEVELS. IN THIS RESPECT DS RESEMBLES XERODERMA PIGMENTOSUM. 2) BY STUDYING THE DNA SEDIMENTATION PROFILES IN ALKALINE SUCROSE GRADIENTS WHICH SHOWED A LESS …
-
Comparison of dose-dependent outcomes in induction of cytogenotoxic responses by novel glucosyl flavonoids
… concentration range of 0.1 and 1,000 ppm induced sister chromatid exchanges (SCE) and micronuclei (MN) in CHO cells. Compared to spontaneous occurrences, significant increases in SCE and MN were observed in both natural and synthetic flavonoid-treated cells in a dose-dependent manner. The natural …
-
A study of inter-individual differences in the DNA damage response
… it. Furthermore, we measured the amounts of sister chromatid exchanges (SCEs) induced by temozolomide treatment to determine if the sensitivity measured by growth inhibition post-treatment was correlated with the amount of temozolomide-induced SCEs. For the cell lines tested, we found that …
-
Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
… radial chromosome aberrations and decreased sister chromatid exchanges after PTEN loss. These results have exciting implications, as it has identified two potential new therapeutic strategies for improving treatment in subsets of GBM patients. The cancer stem cell hypothesis postulates that …
-
A Novel Phosphorylation Site in the Telomeric Protein TRF2 is Regulated by the ATR Kinase and Plays a Role in Relieving Replication Stress at the Telomere
… overhang loss, telomere fusions, and telomere sister chromatid exchanges. TRF2 S368 mutants were able to influence telomere length homeostasis in certain settings in both human and mouse cells. In mouse cells, expression of TRF2 containing a phosphomimetic mutation at position 366 (S366E) …
-
Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma
… resolution of Rad51 foci and higher levels of sister chromatid exchanges (SCEs), which indicated that a higher level of HR was contributing to TMZ resistance in these lines. We have recently shown that CDKs 1 and 2 promote HR in S and G2 phases of the cell cycle, in part, by phosphorylating the …
-
In vitro chemically-induced DNA damage in cancer patients and healthy individuals. The effect of genotoxic compounds in cells from polyposis coli, colon cancer patients and healthy individuals.
… assay, the Micronucleus ¿ FISH assay and the sister chromatid exchange assay. The food mutagens, PhIP and IQ, as well as titanium dioxide nanoparticles (TiO2 NPs) induced a dose dependent increase in the DNA damage and chromosomal abnormalities in all tested groups regardless of confounding …
-
ΕΠΙΔΡΑΣΗ ΤΩΝ ΙΟΝΤΩΝ ΡΟΔΙΟΥ ΣΤΟ ΓΕΝΕΤΙΚΟ ΥΛΙΚΟ ΚΥΤΤΑΡΩΝ ΤΟΥ ΘΗΛΑΣΤΙΚΟΥ CHINESE HAMSTER "ΚΡΙΚΗΤΟΣ ΟΦ ΑΡΓΥΡΟΧΡΟΟΣ"
A RHODIUM COMPLEX (RHCL3.3H2O) WAS ASSAYED IN VITRO, IN A MAMMALIAN CELL LINE (CHV79) AS CYTOSTATIC/MUTAGENIC AGENT AS WELL AS ITS POSSIBLE MECHANISM OF ACTION. ALL THE RESULTS INDICATE A TRANSIENT CYTOSTATIC ACTION DUE AN INTERACTION OFRHODIUM COMPLEX WITH THE DNA MACROMOLECULE. THIS TRANSIENT …