Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Sirtuins (SIRTs)"”.
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Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation
… of HDACs, with particular emphasis on class III (sirtuins, SIRTs). </p> <p>Herein, HDAC class IIa, SIRT1 and SIRT2-selective radiotracers have been developed and validated through in vitro and in vivo characterization. Two of these tracers, 18F-TFAHA for HDAC class IIa and and 2-[18F]PhAHA for …
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Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
… polymerases (PARPs; e.g., PARP-1) or sirtuins (SIRTs; e.g., SIRT-1), which many of them are known to play an important role in gene regulation. In mammalian cells, NAD+ is synthesized from nicotinamide mononucleotide (NMN) and ATP, by the family of enzymes known as nicotinamide …
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Interactions between Folate Deficiency and β-Nicotinamide Adenine Dinucleotide Deficiency and Conformational Study of Thymidylate Synthase and its Physiological Relevance
… poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs). PARP-1 is thought to mediate the repair of BER intermediates and to suppress homologous recombination (HR); SIRT1 is a histone deacetylase. Thus, the balance between folic acid and NAm may regulate the repair of BER intermediates …
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Chronic Gestational Inflammation: Comparisons of Obesity-Mediated and Preeclampsia-Mediated Placental Inflammation using Transcriptomic and Histological Methods
Several obstetrical complications, including maternal obesity (MO) and preeclampsia (PE), are associated with states of chronic gestational inflammation and poor pregnancy outcomes. However, commonalities and/or differences from these divergent chronic inflammatory insults on placental development …