Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Sirtuin-1"”.
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Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
BACKGROUND: Sirtuin-1 (SirT1), an NAD+-dependent deacetylase, is associated with cellular protective effects and beneficial metabolic processes that mimic caloric restriction, increasing cellular stress resistance. Recent studies have shown that SirT1 anti-inflammatory and anti-oxidant effects on …
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SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
… we determined whether enhancing the activity of sirtuin 1 (SIRT1) would be beneficial in maintaining heart health in Chagas disease. We found that treatment with SIRT1 agonists, given in a therapeutic window of time after Trypanosoma cruzi infection, had no beneficial effects in reducing the …
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Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer
… dinucleotide (NAD+) dependent deacetylase Sirtuin 1 (SIRT1) in this impairment of mitophagy/autophagy. Crucially we observed strong support for these key findings in human cancer, where PNC1 expression is inversely correlated with markers of hypoxia signalling, and positively correlated …
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Peripubertal Binge Ethanol, Age and Sex Modulate Microrna Expression in the Ventral and Dorsal Hippocampus of the Adolescent Rat
… brain-derived neurotrophic factor (BDNF) and sirtuin 1 (SIRT1) are differentially expressed in the ventral hippocampus dependent on age and 17β-estradiol (E<sub>2</sub>). We examine whether microRNA expression, microRNA biogenesis enzymes Drosha and Dicer, and microRNA target genes BDNF …
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Regulation of AMPA receptor acetylation and translation by SIRT2 and AMPK: the molecular mechanisms and implications in memory formation
… protein kinase (AMPK) and sirtuin 2 (SIRT2), are described. It is shown that SIRT2, a NAD+-dependent protein deacetylase, directly controls AMPAR stability by regulating AMPAR acetylation. For the first time, we discovered that AMPARs are subject to lysine acetylation, a …
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HIF-2: Standing Guard at the Crossroads of Stress and Aging
… redox-sensing, NAD+ dependent deacetylase enzyme Sirtuin 1, also known as Sirt1 or silent mating type information regulator 2 (Sir2) homolog 1, selectively stimulates HIF-2 alpha signaling during hypoxia. In lower organisms and cell culture models, the FoxO family of transcription factor regulates …
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Effect of benzylglucosinolate on signaling pathways associated with type 2 diabetes prevention
… kinase B (AKT/PKB) and NAD-dependent deacetylase sirtuin-1 (SIRT1). The current study provides evidence that besides of the anticarcinogenic potential, isothiocyanates might have a role in T2D prevention. BITC stimulus mimics the fasting state, in which insulin signaling is not triggered and FOXO …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
… of skeletal muscle repair and regeneration. The sirtuin 1 (Sirt1) protein, a histone deacetylase, has been shown to be involved in many cellular processes, including the differentiation of myoblasts. Although Sirt1 is noted for its role in the differentiation of myoblasts, it is not known if it …