Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Single-nucleus RNA-seq"”.
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Using single nucleus RNA-seq to determine the effect of immunosuppression on the transcriptional activity of resident CNS cells in a mouse model of CNS-TB
… response to CNS-TB, but none have done so atsingle cell resolution. Single nucleus RNA Sequencing (snRNA-seq) was used to determine the effect of immunosuppression on the transcriptional activity of resident CNS cells in a mouse model of CNS-TB. The model consisted of two mouse genotypes, …
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Examining the placenta’s role in neurodevelopment in the context of maternal obesity
… in particular neurodevelopment. Various maternal exposures, such as psychosocial stress, diabetes, infection, and high body mass index (BMI) are associated with higher risks of impaired neurodevelopment in the offspring. One third of women in the United States are affected by maternal obesity …
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The molecular memory of exercise in skeletal muscle
… high intensity and resistance-type exercise. The single nucleus RNA-seq (snRNA-seq) data presented in chapter 4 allowed me to investigate the potential of a cell specific memory of exercise following endurance exercise. Utilizing isolated nuclei from the gastrocnemius muscle of mice fed a control …
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The molecular memory of exercise in skeletal muscle
… high intensity and resistance-type exercise. The single nucleus RNA-seq (snRNA-seq) data presented in chapter 4 allowed me to investigate the potential of a cell specific memory of exercise following endurance exercise. Utilizing isolated nuclei from the gastrocnemius muscle of mice fed a control …
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Derivation of next generation research models of Parkinson’s disease
… diversity within these midbrain organoids using single-cell RNA sequencing (scRNA-seq), revealing the presence of dopaminergic neuron populations resembling in vivo substantia nigra neurons. We demonstrated the utility of the midbrain organoid model by capturing a comprehensive transcriptomic …