Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Single-cell omics"”.
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Droplet-Based Microfluidics for High-Throughput Single-Cell Omics Profiling
… is a powerful tool permitting massive-scale single-cell analysis in pico-/nano-liter water-in-oil droplets. It has been integrated into various library preparation techniques to accomplish high-throughput scRNA-seq, scDNA-seq, scATAC-seq, scChIP-seq, as well as scMulti-omics-seq. These …
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Decoding Disease Drivers Through Single-Cell Omics and Scalable Phenotypic Screens
… in biomedical research, especially in single-cell omics (e.g. single-cell RNA sequencing, single-cell spatial profiling) have given us unprecedented power to decipher the intricate cellular and molecular features that maintain—or disrupt—this balance. However, validating the causality …
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Development of spatial and single-cell omics methods for biochemical profiling of the brain
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿
… to investigate the earliest molecular and cellular alterations that precede the disease. To dissect early events, a transgenic PML-RAR model was used in combination with high-resolution single-cell technologies. Hematopoietic stem cells (HSCs), common myeloid progenitors (CMPs), and a …
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Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF)
… biology involves an intricate balance between cell-intrinsic processes and interactions between cells organized in specific spatial patterns, which can be respectively captured by single-cell profiling methods, such as single-cell RNA-seq (scRNA-seq), and histology imaging data, such as …
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MULTI-OMIC LINEAGE TRACING PREDICTS THE MOLECULAR DRIVERS OF CANCER STEM CELLS IN TRIPLENEGATIVE BREAST CANCER EVOLUTION.
… to dissect without perturbing the native cellular context in which multiple phenotypically distinct subpopulations coexist. Recent advances integrating single-cell omics with different clonal barcoding have begun to uncover features linked to the aggressive behavior of cancer clones. …
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UNDERSTANDING THE CELLULAR AND GENE-REGULATORY MECHANISMS UNDERLYING THE MESENCHYMAL TRANSITION OF EPENDYMOMA TUMOR CELLS USING OMICS APPROACHES
… < 25% and 10-year overall survival rate of 55%. Single-cell transcriptomic analyses of these tumors have identified tumor-derived cell lineages that resemble developmental radial glia cells and a tumor cell population with a mesenchymal gene expression profile that is associated with poor …
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Molecular analysis of germ cell specification
… the correct differentiation of primordial germ cells (PGCs). PGCs are the first cells in the germline, and their correct specification is essential for the eventual production of gametes (eggs and sperm). Murine PGCs arise as a small population in the post-implantation epiblast in response to …
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Decoding Human T Cell Immunity With Single-Cell Multi-Omics
… work, I explore human adaptive immunity through single-cell omics by jointly analysing T cell gene expression and T cell receptor (TCR) sequence modalities. Across several longitudinal infectious disease studies, I identify transient T cell states after infection and link these phenotypes with …
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Quantitative spatial transcriptomics of the developing brain
Developmental and cellular heterogeneity can be studied at the transcriptomic level using RNA sequencing methods, but techniques that quantitatively investigate the spatial dynamics of cell heterogeneity across large tissue areas at a single-cell level are lacking. Applying this capability to the …
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Spatio-temporal regulation of pre-symbiotic signalling in arbuscular mycorrhizal symbiosis
… colonises the plant root system and cortex cells. Symbiosis development must therefore require spatio-temporally fine-tuned molecular control mechanisms. Although the plant genetic programme underlying AM symbiosis has been extensively studied, little is known about its dynamic regulation …