Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Single-Cell Biology"”.
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A microwell array cytometry system for high throughput single cell biology and bioinformatics
Recent advances in systems biology and bioinformatics have highlighted that no cell population is truly uniform and that stochastic behavior is an inherent property of many biological systems. As a result, bulk measurements can be misleading even when particular care has been taken to isolate a …
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Some Problems in Stochastic Dynamics and Statistical Analysis of Single-Cell Biology of Cancer
… now has easy access to cancer related data on a single cell, its genome and/or molecular compositions. At this level of description, stochasticity is a significant component of the dynamics. Statistics also emerge naturally from stochastic data. In the first part, we study the cancer cell growth …
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Machine Learning Approaches to Multi-Modal Data Integration and Translation in Single-Cell Biology
Building a complete picture of cell state requires measuring different properties of the cells, such as their gene expression, morphology, etc., and understanding 1) how these properties relate to each other, 2) how they change over time, 3) how they are affected by different perturbations. It is …
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Integrating discrete stochastic models with single-cell and single-molecule experiments
… experiments can capture the behaviors of single biomolecules within single cells. Much like Robert Brown looking at pollen grains in water, experimentalists have noticed that individual cells that are genetically identical behave seemingly randomly in the way they carry out their most …
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DNA methylation: a model system for the study of ageing
… in prevalence with age are not caused by all cells within the individual, but are often the result of changes to a subset of cells. This underscores the importance of studying these processes at the single cell level. The recent advances in single cell sequencing approaches now mean that we …
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Continuous focusing and separation of microparticles with acoustic and magnetic fields
… important role for applications that involve single cell biology and the detection and diagnosis of diseases. In microfluidic devices, methods that are commonly used to manipulate cells or particles include the utilization of hydrodynamic effects and externally applied field gradients that …
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Automation of Single Cell Micromanipulation and Microsurgery for Blastocyst Embryo Biopsy
Abstract: The recent growing interest in single cell biology demonstrates that micromanipulation and microsurgical advance strategies are required to carry out single cell surgical processes, such as the Preimplantation Genetic Diagnosis (PGD). To perform PGD, a sample from the inner material of …
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Characterizing RNA translocation in the parasitic weed Cuscuta pentagona
… organ known as the haustorium. Direct cell-to-cell symplastic connections between two different organisms are rare, and the translocation mechanisms and fate of these RNAs in the parasite is not understood. To characterize this phenomenon, mobile Arabidopsis and tomato mRNAs were …
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3D Nanoscale Architecture and Physiology of the Human Airway Epithelium
Understanding how transcriptional changes lead to cellular-level architectural changes that drive cellular function is a central challenge in single-cell biology. An example of cellular remodelling is observed in the differentiation of airway basal stem cells into multiciliated cells within the …
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The Effects of Methyltransferase Genes on Human Haematopoietic Stem Cell Function
… the existence of a pool of haematopoietic stem cells (HSCs) at the apex, which possess both multipotent differentiation and self-renewal properties. The HSC pool is heterogenous in terms of self-renewal and differentiation capacity, and HSCs with various genetic alterations lie intermingled with …
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Hyphenation of analytical techniques to single cell capillary electrophoresis-mass spectrometry
Single cell chemical analysis pushes the limits of analytical measurements. Small volumes, large dynamic range, and chemical complexity all contribute to the analytical challenge of investigating single cell biology. To comprehensively study single cell chemistry, technologies require low limits of …
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Smart microscopy methods for quantitative microbiology
Quantitative microbiology seeks to provide insights into bacterial behaviour, growth, and interaction. Widefield fluorescence microscopy, in particular, has revolutionised this field by enabling high-throughput, non-invasive, time-lapse observations of cellular processes at the single-cell level. …