Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Single nucleotide substitutions"”.
-
Experimental and Computational Dynamics of an Aminoacyl-tRNA Synthetase System
… MetRS and tRNAMet, we made tRNA variants with single nucleotide substitutions in conserved core nucleotide, and MetRS variants with changes in the connective polypeptide. MetRS contains a highly mobile connective polypeptide (CP) domain which contains a β-linker, which is unique to MetRS …
-
Optimization of Molecular Beacon-Based Multicomponent Probes for Analysis of Nucleic Acids
Detection of single nucleotide substitutions (SNS) in DNA and RNA has a growing importance in biology and medicine. One traditional approach for recognition of SNS takes advantage of hybridization probes that bind target nucleic acids followed by measuring ?Tm, the difference in melting …
-
The translation initiation site of satellite tobacco necrosis virus RNA does not require a start codon
… mRNAs. In order to examine this theory, oligonucleotide directed site specific mutagenesis of pSTNV$\sb{1239}$ and pSP65-A4 plasmids containing full length cDNA clones of STNV RNA and AMV-4 RNA was used to generate single nucleotide substitutions in the translation initiation region of these …
-
Rice Blast Disease in the U.S. and Africa: Determination of Pathogen Diversity and the Identification of Resistance Genes for Disease Management
… isolates from both the U.S. and Africa. No single genotype or R gene was effective against all isolates from both Africa and the U.S. Blast control in the U.S could be achieved by introgression of Pi9 and Pi11 into rice cultivars. In West Africa, blast control could be achieved by …
-
Mechanism of resistance to tyrosine kinase inhibitors in philadelphia-positive acute lymphblastic leukaemia (all): from genetic alterations to impaired RNA editing
… associated with adult ALL and it represents the single most significant adverse prognostic marker. Despite imatinib has led to significant improvements in the treatment of patients with Ph+ ALL, in the majority of cases resistance developed quickly and disease progressed. Some mechanisms of …
-
Application of High Resolution Melting analysis for haplotype detection in phylogeographic research and case studies of Arenaria ciliata, A. norvegica and Minuartia recurva (Caryophyllaceae)
… sensitivity is evaluated to different classes of single nucleotide substitutions. Class I and II class I (A/G or C/T) and II (A/C or G/T) substitutions are demonstrated easier to be detected than class III (C/G) and IV (A/T) substitutions. Further analyses suggest that between 50 and 650bp, …
-
ERG11-Mediated Azole Resistance in Candida albicans
… here, I repeatedly recovered eight distinct single-nucleotide substitutions in <em>UPC2</em>. Five of these substitutions in <em>UPC2</em> have not been described previously. Of the five novel mutations, four mutations resulted in increased ERG11 expression and increased resistance to …